【摘要】 P2X受体(P2X receptor, P2XR)家族是三磷酸腺苷(adenosine triphosphate,ATP)配体门控的非选择性阳离子通道。目前已经克隆出的哺乳动物P2XR有7种,分别为P2X1～7,并且其药理学特性也有了一定的研究进展。天然P2XR组装的同源或异源三聚体离子通道,可以参与多种生理学功能。本文就P2XR的结构、功能及其在肺部疾病中的研究进展进行综述。更多还原

【Abstract】 P2X receptors are ATP-gated nonselective cation channels. At present, seven mammalian P2XRs have been cloned, which are P2X1～7, and their pharmacological properties have been studied in a certain extent.Homologous or heterotrimeric ion channels assembled by natural P2XRs can participate in many physiological functions.Therefore, this article mainly reviews the structure, function and research progress of P2XR in lung diseases.更多还原