【摘要】 目的:探讨复发蟾蝎胶囊联合干扰素α-1b预防小肝癌根治术后复发的临床疗效。方法:回顾性分析50例小肝癌行根治性切除或射频消融术后临床病例资料,治疗组应用复发蟾蝎胶囊联合干扰素α-1b预防复发,给予干扰素α-1b(赛若金)500万U肌内注射,隔天1次;复发蟾蝎胶囊5粒/次,3次/d,疗程12个月。对照组应用肝动脉化疗栓塞(TACE)预防复发,治疗3次,每月1次。对两组患者1年、2年、3年无瘤生存率、总生存率、肿瘤复发率进行对比研究。结果:治疗组1年、2年、3年无瘤生存率分别为100%、84%、72%,对照组相应为92%、72%、60%;治疗组1年、2年、3年总生存率分别为100%、96%、84%,对照组相应为96%,84%,68%;治疗组1年、2年、3年肿瘤复发率分别为0%、16%、28%,对照组相应为8%、28%、40%。治疗组1年、2年、3年的无瘤生存率、总生存率高于对照组,差异均有统计学意义(P<0.05),而治疗组的肿瘤复发率低于对照组,差异有统计学意义(P<0.05)。结论:复发蟾蝎胶囊联合干扰素组较TACE组对预防小肝癌根治术后复发有较好的作用。更多还原

【Abstract】 Objective To evaluate the clinical efficacy of compound toad scorpion capsule combined interferon alpha 1 b in preventing the recurrence of primary liver cancer after radical surgery.Method The clinical data of 50 patients with primary hepatic carcinoma treated by radical resection or radiofrequency ablation were analyzed retrospectively.The patients were divided into the treatment group(n=25) and control group(n=25).The treatment group used compound toad scorpion capsule combined therapy with interferon alpha 1 b prevent recurrence.5 grain of compound toad scorpion capsule was orally administered three times daily for consecutive 12 months.5 million U intramuscular of interferon alpha 1 b was injected once every two days for 12 months.The control application of transcatheter arterial chemoembolization(TACE) prevent recurrence once a month for a total of 3 times.1,2,3,disease-free survival and overall survival rate,tumor recurrence were evaluated and compared between two groups.Results In the treatment group,the 1-,2-and 3-year disease-free survival rates were 100%,84%,72%,respectively, and 92%,72%,60% respectively in the control group.In the treatment group,the 1-,2-and 3-yeartotal survival rates were 100%,96%,84%,and 96%,84%,68% respectively in the control group.In the treatment group,the 1-,2-and 3-year tumor recurrence rates were 0%,16%,28%,and 8%,28%,40% respectively in the control group.Treatment group 1,2,3 years of disease-free survival and overall survival was significantly higher than the control group,the differences were statistically significant(P<0.05),and tumor recurrence rates significantly lower than the control group,the difference was statistically significant(P<0.05).Conclusion Compound toad scorpion capsule combined interferonhas better effect than conventional TACE group in preventing the recurrence of primary liver cancer.更多还原