【摘要】 目的:探讨耳穴迷走神经持续电刺激对无先兆偏头痛(MWoA)患者脑功能区域神经活动的影响。方法:采用随机自身交叉对照,将招募的MWoA患者(27例)分为A组(15例)与B组(12例),A组先接受持续8 min耳穴迷走神经刺激,1周后接受非迷走神经持续刺激;B组先接受持续8 min非迷走神经刺激,1周后接受耳穴迷走神经刺激。应用Siemens 3.0 T MRI采集刺激态的全脑功能图像,通过DPABI 3.0及SPM 12软件对比分析非迷走神经刺激与耳穴迷走神经刺激时患者的比率低频振幅(f ALFF)差异。结果:与非迷走神经刺激相比,耳穴迷走神经持续刺激时MWoA患者双侧孤束核、右侧后扣带回、左侧小脑及双侧丘脑的f ALFF值显著升高(均P<0.05)。结论:耳甲穴迷走神经持续刺激可对脑默认网络和疼痛矩阵产生影响,为揭示针刺耳穴治疗偏头痛机制提供了理论依据。更多还原

【Abstract】 Objective:To investigate the effect of auricular acupoints continuous stimulation on neural activity of functional brain areas in patients with migraine without aura(MWoA). Methods:In a randomized self-crossover study,27 patients with MWoA were randomly divided into Group A(n=15) and Group B(n=12). The patients of Group A were stimulated for 8 minutes at auricular acupoints with vagus nerve,then auricular acupoints with non-vagus nerve after one week,which was opposite in Group B. MRI was used to collect functional images during stimulation. The difference of fraction amplitude of low-frequency fluctuation(f ALFF) in functional brain areas between vagus stimulation and non-vagus stimulation were analyzed using DPADI 3.0 and SPM 12 softwares. Results:Compared with non-vagus stimulation,the f ALFF during vagus stimulation in bilateral solitary nucleus,right posterior cingulateus,bilateral thalamus and left cerebellum were significantly higher(P< 0.05). Conclusion:The vagus stimulation at auricular points can regulate the functional activity of brain networks participated in the regulation of pain,providing data support to treat MWoA.更多还原