【摘要】 目的:探讨多囊卵巢综合征(PCOS)患者性激素结合球蛋白(SHBG)水平与糖脂代谢关系。方法:选取本院接诊的185例PCOS患者(观察组)及同期体检的120例健康育龄女性(对照组),观察组根据SHBG水平分为两个亚组,行血清激素、血糖及血脂检测,分析SHBG与糖脂代谢的关系。结果:低SHBG组的FAI、AND、DHEAS、TG、TC、ApoB、FPG、FINS、HOMA-IR水平均高于SHBG正常组,HDL-C、ApoA水平均低于SHBG正常组(P<0.05),SHBG正常组与对照组上述各指标比较无差异(P>0.05)。PCOS患者的SHBG水平与HDL-C、ApoA有正相关关系,与DHEAS、AND、FAI、FINS、HOMA-IR、ApoB均有负相关关系(P均<0.05)。结论:低SHBG PCOS患者更易发生血糖、血脂异常,SHBG水平降低可能是患者发生血脂紊乱的危险因素。更多还原

【Abstract】 Objective: To investigate the relationship between sexes hormone binding globulin(SHBG) level and glycolipid metabolism of women with polycystic ovary syndrome(PCOS). Methods: 185 women with PCOS and 120 healthy women of childbearing age who were received physical examination during the same period were selected into the observation group and the control group, and women in the observation group were further divided into two subgroups according to the level of SHBG. The levels of serum SHBG, sex hormone, blood glucose and lipid of all included women were detected, and the relationship between SHBG and glycolipid metabolism was analyzed. Results: The levels of FAI, AND, DHEAS, TG, TC, ApoB, FPG, FINS and HOMA-IR of women with low SHBG level were significant higher than those of women with normal SHBG level, but the HDL-C and ApoA levels were significant lower than those of women with normal SHBG level(P<0.05). There were no significant different in the levels of FAI, AND, DHEAS, TG, TC, ApoB, FPG, FINS, HOMA-IR, HDL-C and ApoA between the normal women and the women with PCOS and normal SHBG level(P>0.05). Correlation analysis showed that the SHBG level of PCOS patients was positively correlated with the levels of HDL-C and ApoA, and was negatively correlated with the levels of DHEAS, AND, FAI, FINS, HOMA-IR and ApoB(P<0.05). Conclusion: The women with PCOS and low SHBG level are more likely to have abnormal glycolipid metabolism, and the decrease of SHBG level may be a risk factor for dyslipidemia of women with PCOS.更多还原