【摘要】 目的:探究尼莫地平联合丹参川芎嗪注射液对妊娠期高血压的疗效及对LIF、Apelin表达影响。方法:选取本院2016年4月—2017年4月收治的妊娠期高血压疾病患者120例,使用随机数字表法分为观察组及对照组各60例。对照组采用硫酸镁+拉贝洛尔治疗,观察组在此基础上加用尼莫地平及丹参川芎嗪注射液,连续治疗14d。比较两组治疗效果,治疗前后收缩压、舒张压、平均动脉压、心率及24h尿蛋白水平,血清白细胞抑制因子(LIF)及脂肪因子(Apelin)水平,记录用药期间不良反应发生情况及母婴结局。结果:观察组治疗总有效率(90.0%)高于对照组(75.0%)(P<0.05),收缩压、舒张压及平均动脉压均低于对照组(P<0.05),心率及24h尿蛋白水平均低于对照组(P<0.05),血清LIF水平高于对照组,Apelin水平低于对照组(P<0.05);两组不良反应发生率无统计学差异(P>0.05)。结论:尼莫地平联合丹参川芎嗪注射液治疗可有效控制血压、减少24h尿蛋白、调节LIF、Apelin水平,安全可靠。更多还原

【Abstract】 Objective:To explore the curative effect of nimodipine combined with salvia miltiorrhiza ligustrazine injection for treating pregnant women with pregnancy induced hypertension and its influence on the expression of LIF and Apelin.Methods:120pregnant women with hypertension were selected from Heping district maternity hospital of Tianjin from April 2016 to April 2017,and they were divided into study group and control group by random number table(60cases in each group).The pregnant women in control group were treated by nimodipine for 14 days,and the pregnant women in study group were treated by nimodipine combined with salvia miltiorrhiza ligustrazine injection for14 days.The therapeutic effects of pregnant women were compared between the two groups.The value of systolic blood pressure,diastolic blood pressure,and mean arterial pressure,and heart rate,level of 24 hurinary protein,and levels of serum leukocyte inhibition factor(LIF)and adipokines Apelin of pregnant women in both groups were also compared before and after treatment.The adverse reactions of pregnant women during pregnancy and the maternal and neonatal outcomes in the two groups were recorded.Results:The total effective rate of study group(90.0%)was significant higher than that(75.0%)of the control group(P<0.05).The value of systolic blood pressure,diastolic blood pressure and mean arterial pressure of pregnant women in study group were significant lower than those of pregnant women in control group(P<0.05),and the heart rate,24 hurinary protein level,and level of Apelin of pregnant women in study group were also significant lower than those of pregnant women in control group(P<0.05),but the LIF level of pregnant women in study group were significant higher than that of pregnant women in control group(P<0.05).There was no significant different in the incidence of adverse reactions of pregnant women between the two groups(P>0.05).Conclusion:Nimodipine combined with salvia miltiorrhiza ligustrazine injection for treating pregnant women with pregnancy induced hypertension can effectively control blood pressure,can reduce 24-hour urine protein level,and can regulate the level of LIF and Apelin,which is safe and reliable.更多还原