【摘要】 目的探究维生素A、E缺乏与子痫前期(preeclampsia,PE)的相关性。方法选择上海中医药大学附属第七人民医院产科2016年5月至2018年5月收治的PE患者100例,根据病情严重程度分为轻度PE组(39例)和重度PE组(61例),另选择50例正常孕妇为对照组。采用高效液相色谱法检测各组孕妇血清维生素A、E水平,并于孕妇分娩后收集病例资料进行分析统计。结果重度PE组年龄、产前体质量指数(body mass index,BMI)及增幅BMI[(36.58±6.20)岁、(30.10±4.12)kg/m~2、(6.14±1.78)kg/m~2]均显著高于轻度PE组[(31.17±4.10)岁、(28.36±3.79)kg/m~2、(5.78±1.72)kg/m~2]与对照组[(28.24±4.28)岁、(26.70±3.21)kg/m~2、(5.33±1.59)kg/m~2],轻度PE组年龄、产前BMI及增幅BMI均显著高于对照组,差异均有统计学意义(P<0.05);重度PE组维生素A、E水平[(0.29±0.12)mg/L、(14.61±3.52)mg/L]显著低于轻度PE组[(0.35±0.10)mg/L、(17.13±2.7)mg/L]与对照组[(0.39±0.07)mg/L、(18.02±4.47)mg/L],维生素A、E缺乏率(34.4%、50.8%)显著高于轻度PE组(25.6%、35.9%)与对照组(22.0%、24.0%),轻度PE组维生素A、E水平显著低于对照组,维生素A、E缺乏率显著高于对照组,差异均有统计学意义(P<0.05);Logistic回归性分析结果显示,高龄及维生素A、E缺乏是影响PE的独立危险因素。结论维生素A、E缺乏可能是PE发生的独立危险因素,可能参与PE的发生发展。应在孕期适当补充维生素A、E,预防PE发生。更多还原

【Abstract】 Objective To explore the correlation between vitamins A and E deficiency and preeclampsia(PE) during pregnancy. Methods 100 cases of patients with PE who were admitted to Department of Obstetrics and Gynecology,the Seventh People’s Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from May 2016 to May 2018 were selected and divided into mild PE group(n=39) and severe PE group(n=61) according to the severity of illness. Another 50 normal pregnant women were selected as control group. Serum levels of vitamin A and vitamin E in pregnant women of each group were determined by high-performance liquid chromatography, and the cases data were collected after maternal delivery for analytic statistics. Results The age, prenatal BMI and increased BMI in severe PE group[(36.58±6.20)years of age,(30.10±4.12)kg/m~2,(6.14±1.78)kg/m~2] were significantly higher than those in mild PE group[(31.17±4.10)years of age,(28.36±3.79)kg/m~2,(5.78±1.72)kg/m~2] and control group[(28.24±4.28)years of age,(26.70±3.21)kg/m~2,(5.33±1.59)kg/m~2], and the age, prenatal BMI and increased BMI in mild PE group were significantly higher than those in control group(P<0.05). The levels of vitamin A and E in severe PE group [(0.29±0.12) mg/L,(14.61±3.52) mg/L] were significantly lower than those of mild PE group [(0.35±0.10) mg/L,(17.13±2.7) mg/L] and control group [(0.39±0.07) mg/L,(18.02±4.47) mg/L], vitamin A, E deficiency rate(34.4 %, 50.8 %) were significantly higher than those of the mild group(25.6 %,35.9 %)and control group(22.0 %,24.0 %). The levels of vitamin A and E in the mild PE group were significantly lower than those in the control group, and the deficiency rates of vitamin A and E were significantly higher than those in the control group.(P<0.05). Logistic regression analysis showed that the advance age and deficiency of vitamins A and E were independent risk factors for PE. Conclusion Vitamin A and E deficiency may be independent risk factors for PE, and it may participate in the occurrence and development of PE. Vitamins A and E should be supplemented properly during pregnancy to prevent the occurrence of PE.更多还原