【摘要】 目的 应用事件相关电位P300技术研究双相障碍抑郁发作患者认知电位的特点。方法 选择32例双相障碍抑郁发作患者(患者组,包括双相Ⅰ型障碍8例,双相Ⅱ型障碍24例)和30名健康对照(对照组),采用经典的视觉怪球范式进行P300测试,对行为学数据及P300成分进行比较分析。结果 患者组按键准确率[(85.42±9.33)%]低于对照组[(89.88±6.84)%],差异有统计学意义(P<0.05);患者组多个电极位点的P300波幅低于对照组,差异有统计学意义(P<0.05);进一步分析发现双相障碍抑郁发作伴有精神病性症状的患者在电极位点FP1 [(570.00±208.65)ms]、F7 [(505.20±184.50)ms]的P300潜伏期较不伴有精神病性症状者[(411.59±196.52)、(371.76±142.80)ms]延长,差异有统计学意义(P<0.05)。结论 双相障碍抑郁发作患者的认知功能存在一定程度受损,在视觉P300中主要表现为波幅的降低,其中双相障碍抑郁发作伴有精神病性症状患者较不伴有精神病性症状者在FP1、F7位点潜伏期延长。更多还原

【Abstract】 Objective To study the characteristics of cognitive potential in patients with depressive episode of bipolar disorder by event-related potential P300.Methods Totals of 32 patients with depressive episode of bipolar disorder(patient group,including 8 patients with bipolar I disorder and 24 with bipolar Ⅱdisorder) and 30 healthy controls(control group) were recruited.P300 test was conducted using the classic visual oddball paradigm.Behavioral data and P300 components were compared and analyzed.Results The accuracy of keystroke in the patient group [(85.42±9.33)%] was lower than that in the control group [(89.88±6.84)%],and the difference was statistically significant(P <0.05).The amplitude of multiple electrode sites in the patient group was lower than that in the control group,and the difference was statistically significant(P<0.05).Further analysis showed that the P300 latency of bipolar depressive episode patients with psychotic symptoms at the electrode site FP1 [(570.00±208.65) ms],F7 [(505.20±184.50) ms] was longer than that of patients without psychotic symptoms [(411.59±196.52),(371.76±142.80) ms],and the difference was statistically significant(P <0.05).Conclusions The cognitive function of patients with bipolar depressive episode is impaired to a certain extent,which is mainly manifested in the decrease of amplitude of visual P300,the latency at sites FP1 and F7 are longer in the bipolar depressive episode patients with psychotic symptoms than in the group without psychotic symptoms.更多还原