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催产素在孤独症谱系障碍患者中的可能作用机制进展

Possible mechanism reserch progress of oxytocin in patients with autism spectrum disorders

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【作者】 姜幸智闫晓娜郑薇王文强

【Author】 Jiang Xingzhi;Yan Xiaona;Zheng Wei;Wang Wenqiang;School of Medicine,Xiamen University;School of Nursing, Fujian University of Traditional Chinese Medicine;Psychiatry Department, Xianyue Hospital;

【通讯作者】 王文强;

【机构】 厦门大学医学院福建中医药大学护理学院厦门市仙岳医院精神科

【摘要】 孤独症谱系障碍(ASD)是一种神经发育障碍性疾病。该疾病起源于婴幼儿期,主要表现为不同程度的社会交往障碍、语言发育障碍、兴趣狭窄和行为方式刻板三组症状。迄今为止尚无针对该疾病的特效药物,但是有研究表明催产素的缺乏或利用不足是导致ASD患者社会交往障碍原因之一,因此关于催产素与ASD的研究受到了广大学者的青睐。现对催产素作用于ASD患者的症状改善情况、不良反应及运用前景等进行总结,为临床运用催产素治疗ASD患者提供帮助。

【Abstract】 Autism spectrum disorder(ASD) is a neurodevelopment disorder.The disease originated in infancy and manifested in three groups of symptoms,including different degrees of social communication disorder,language development disorder,narrow interest and rigid behavior.So far,there is no specific drug for the disease,but some studies show that oxytocin deficiency or underutilization is one of the causes of social interaction disorder in ASD patients.Therefore,studies on the effects of oxytocin on ASD have attracted attention from many scholar.This paper summarizes the symptom improvement,adverse reactions and application prospect of oxytocin in ASD patients,so as to explore new ideals for future research,and provide help for using OT to treat ASD clinically.

【关键词】 孤独症谱系障碍催产素综述
【Key words】 Autism spectrum disorderOxytocinReview
【基金】 国家重点研发计划(2017YFC1309900)~~
  • 【文献出处】 神经疾病与精神卫生 ,Journal of Neuroscience and Mental Health , 编辑部邮箱 ,2019年08期
  • 【分类号】R749.94
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