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童年创伤对健康青年认知功能的影响

Impact of childhood trauma on cognitive function in the healthy young adults

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【作者】 吴韦玮肖迎春黄华品陆邵佳位照国李凌江魏永宝

【Author】 Wu Weiwei;Xiao Yingchun;Huang Huapin;Lu Shaojia;Wei Zhaoguo;Li Lingjiang;Wei Yongbao;Department of Neurology,Union Hospital,Fujian Medical University;Department of Psychiatry,the First Affiliated Hospital of Zhejiang University;Department of Psychiatry,Shenzhen Mental Health Center,Kangning Hospital;Mental Health Institute of The Second Xiangya Hospital,Key Laboratory of Psychiatry and Mental Health of Hunan Province,Central South University;Department of Urology,Fujian Provincial Hospital;

【通讯作者】 吴韦玮;

【机构】 福建医科大学附属协和医院神经内科浙江大学附属第一医院精神科深圳市康宁医院精神科中南大学湘雅二医院精神病学与精神卫生学湖南省重点实验室福建省立医院泌尿外科

【摘要】 目的 评估童年创伤对健康青年成人认知功能的影响。方法 2012年2月以来3次利用童年创伤问卷筛查出有童年创伤以及不伴任何形式童年创伤的健康青年,分别完成威斯康星卡片分类测验(WCST)、Stroop测验及韦氏记忆量表(WMS)连线测验、词语流畅测验等评估。结果 伴童年创伤组(n=90)在词语流畅性测验、WMS视觉再生分测验以及WCST中正确应答数、错误应答数、持续错误数及完成分类数与无童年创伤组(n=104)相比差异有统计学意义,童年创伤总分与视觉再生结果呈负相关,与连线测验B、WCST错误应答数呈正相关,不同童年创伤类型的数量与Stroop测验、WCST正确应答数、WMS部分结果呈负相关(均P<0.05)。结论 伴童年创伤的健康青年的认知功能受损,童年创伤越严重或不同创伤数量越多,认知功能越差。

【Abstract】 Objectives To assess the impact of childhood trauma on cognitive function in healthy young adults.Methods Three times since February 2012,the Childhood Trauma Questionnaire(CTQ)was used to screen out healthy young people with childhood trauma and without any form of childhood trauma.These participants were then evaluated using the Wisconsin Card Sorting Test(WCST),the Stroop Test,Trail Making Test,Verbal Fluency Test,and the Wechs Memory Scale(WMS).Results The performance of young adults with childhood trauma(n=90)was significantly different in the Verbal Fluency Test,the visual regenerative test of WMS and WCST compared with those with no childhood trauma(n=104).The total score of CTQ was negatively correlated with results of Visual Reproduction and Trail Making Test B,while it was positively correlated with results of WCST ervor response; the number of different types of childhood trauma was negatively correlated with the Stroop test,number of WCST correct response and partial results and partial results of WMS(all P < 0.05).Conclusions The cognitive function of healthy young people with childhood trauma is impaired.The more severe the trauma in childhood or the higher the number of different traumas,the worse is their cognitive function.

【基金】 国家自然科学基金(81171286,91232714);福建省科技创新联合资金项目(2017Y9064)~~
  • 【文献出处】 神经疾病与精神卫生 ,Journal of Neuroscience and Mental Health , 编辑部邮箱 ,2019年03期
  • 【分类号】R195
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