【摘要】 失眠是临床常见症状,多与抑郁和焦虑障碍等精神疾病同时或相继发生,且临床上常难以界定两者之间的因果关系。鉴于失眠与抑郁、焦虑存在的交互作用,对抑郁、焦虑和失眠进行综合干预和管理成为目前疾病治疗的新趋势。曲唑酮是一种具有镇静催眠作用的抗抑郁药,临床广泛用于失眠及抑郁焦虑伴发或共病失眠的患者。为规范曲唑酮在失眠领域的应用,编写共识的专家组成员通过复习曲唑酮相关文献,同时结合国内外指南的推荐,重新总结了药物的药代动力学数据、药理作用及相关临床应用方法,并经过专家组的反复讨论达成共识,以期为广大临床医师合理使用该药提供参考。更多还原

【Abstract】 Insomnia is a common clinical problem. It can be comorbid with other psychiatric disorders such as major depressive disorder(MDD) and anxiety disorder(AD), which leads to hard definition of causality between insomnia and MDD/AD. In view of the mutual relationship between insomnia and MDD/AD, Comprehensive intervention of both insomnia and MDD/AD has become a new trend. Trazodone, an antidepressant with sedative and hypnotic effects, is widely used in management of insomnia, depression and anxiety. In order to standardize the clinical practice of trazodone in treatment of insomnia, the experts committee of comorbid insomnia reviewed recent evidence and recommendations of guildelines, summarized the pharmacokinetics data, pharmacological effects and clinical applications of trazodone. After repeated discussions by the committee, the consensus was finally completed, which can provide useful clinical suggestion to physicians.更多还原