【摘要】 探讨促性腺激素释放激素激动剂(GnRH-α)与反向添加疗法治疗子宫内膜异位症(EMS)对患者生殖激素、血清糖类抗原125(CA125)、肿瘤坏因子-α(TNF-α)、白细胞介素-18(IL-18)水平的影响。比较患者治疗前后血清雌二醇(E2)、卵泡刺激素(FSH)、黄体生成素(LH)、糖类抗原(CA125)、肿瘤坏因子-α(TNF-α)、白细胞介素-18(IL-18)、视觉模拟疼痛评分(VAS评分)、更年期症状评分(Kupperman评分)。结果显示,GnRH-α与反向添加疗法治疗后,患者血清E2水平升高;血清TNF-α、IL-18水平降低;VAS评分、Kupperman评分降低。本研究表明,GnRH-α联合反向添加疗法治疗EMS患者较单纯使用GnRH-α治疗有利于维持雌激素水平、进一步减轻疼痛及围绝经期症状。更多还原

【Abstract】 To investigate the effects of gonadotropin-releasing hormone agonist(GnRH-α) and reverse-addition therapy on endometriosis(EMS) in patients with reproductive hormone, serum carbohydrate antigen 125(CA125), tumor-derived factor-α(TNF-The effects of α) and interleukin-18(IL-18) levels. Serum estradiol(E2), follicle stimulating hormone(FSH), luteinizing hormone(LH), carbohydrate antigen(CA125), tumor-derived factor-α(TNF-α), interleukin-18(IL-18), visual analogue pain score(VAS score) and menopausa symptom score(Kupperman score) were compared before and after treatment. Results showed that after treatment with GnRH-α and reverse-addition therapy, serum E2 level increased, serum TNF-α-IL-18 level decreased and Kupperman score decreased. Although GnRH-α combined with reverse addition therapy in patients with EMS is more effective than GnRH-α alone in maintaining estrogen levels, further reducing pain and perimenopausal symptoms.更多还原