【摘要】 微球是一种新型药物载体,具有很大的开发与应用潜力.天然高分子具有良好的生物相容性、可降解性,易在生物体内分散,可制备成微球.无机材料(主要为无机矿物)力学性能优良,且价廉易得.通过天然高分子与无机材料两者耦合杂化作用,可优势互补、协同增效,进而产生许多优异的理化性能.使用无机材料改性天然高分子,通过乳化交联法、溶液混合法、原位合成法、挤出法等多种方法可制备得到无机材料/天然高分子复合微球.将无机材料/天然高分子复合微球应用于药物传递系统中,缓释效果明显,安全无毒害,且载体材料价格相对低廉,对于开发新型药物载体具有一定的意义.本文综述了近年无机材料/天然高分子复合微球的制备、载药与释药性能的相关研究,分析了常用制备方法的利弊,展望了复合微球的发展方向.更多还原

【Abstract】 As a new drug-carrier, microsphere had great potential for development and application. Natural materials with good biocompatibility, biodegradability and easily dispersal in an organism, could be prepared into microspheres. Inorganic materials, mainly including inorganic mineral, had good mechanical properties, that was cheap and widespread. By the coupling of natural polymer materials and inorganic materials, the advantages could be complementary and synergistic, resulting in many excellent physical and chemical properties. Through many methods, including emulsion crosslinking, solution mixing, in-situ synthesis, extrusion, inorganic/natural polymer composite microspheres could be prepared by modifying natural polymers with inorganic materials. The application of natural polymer/inorganic composite microspheres in drug delivery system had obvious slow-release effect, safety and non-toxic, and the price of carrier material was relatively low, which had certain significance for the development of new drug carrier. In this paper, the preparation, morphology regulation, drug loading and drug release properties of inorganic/natural materials composite microspheres were reviewed. On the basis of the results, the research and application of composite microspheres in the future was promising.更多还原