【摘要】 目的:探索原发性支气管肺癌病理类型与中医证型的相关性。方法:以"肺癌""病理""证"为关键词,从CNKI、万方、CBM、Pubmed、Embase、Cochrane数据库检索原发性支气管肺癌病理类型与中医证型相关性的前瞻性研究,确立肺癌中医基本证型,使用确切概率法分析中医证型与病理类型的关系。结果:最终纳入文献共7篇,共1075例患者,肺腺癌占48.7%,肺鳞癌占34.4%,小细胞癌占4.2%,大细胞癌占3.7%。中医证型主要为气虚证(22.1%)、气阴两虚证(17.5%)、阴虚热证(13.3%)、肺阴虚(12.7%)、气滞血瘀证(12.6%)等。其中腺癌与鳞癌、大细胞癌,以及小细胞癌与大细胞癌间的中医证候分布差异有统计学意义(P<0.01),鳞癌与大细胞癌间的中医证型分布差异有统计学意义差异(P<0.05)。结论:原发性支气管肺癌病理类型与中医证型是相关的,不同病理类型之间中医证候分布存在一定的差异;原发性支气管肺癌以气虚和阴虚为本,腺癌兼化热;鳞癌气滞血瘀证亦较多;小细胞癌易出现痰湿证;大细胞癌以阴虚热证、气阴两虚证、气滞血瘀证为主。更多还原

【Abstract】 Objective: To investigate the relationship between histopathologic types of primary lung cancer and traditional Chinese medicine(TCM) syndromes. Methods: Searching the prospective study on the correlation between the pathological types of primary lung cancer and TCM syndromes by CNKI, Wanfang, CBM, Pubmed,Embase and Cochrane retrieval systems, with "lung cancer", "pathology" and " TCM syndromes" as keywords.Based on this, establishing Chinese Medicine basic syndrome type of lung cancer and applying Fisher’s exact probability test to analyze the relationship between TCM syndrome type and pathological type. Results: A total of 7 Chinese articles were concluded of 1075 primary lung cancer patients which comprised of adenocarcinomas(48.7%), squamous cell carcinoma(34.4%), small-cell lung cancer(4.2%) and large cell carcinoma(3.7%). The distribution of TCM Syndromes are mainly Qi-deficiency syndrome(22.1%), Qi-Yin deficiency syndrome(17.5%),Yin deficiency and blood heat(13.3%), Lung Yin deficiency(12.7%), Qi-stagnancy and blood stasis(12.6%). The TCM syndromes distribution of adenocarcinoma, squamous cell carcinoma and large cell carcinoma have statistical significance(P<0.01), as well as small-cell lung cancer and large cell carcinoma(P<0.05), squamous cell carcinoma and large cell carcinoma(P<0.05). Conclusion: Pathological classification of primary lung cancer and TCM syndrome types are related. The statistical significance presented in the syndromes of Chinese medicine among different pathological subtypes. Primary lung cancer is mostly manifested as Qi-deficiency or Yin-deficiency of the root cause. Based on these, adenocarcinoma can easily turn into heat syndromes. And the most common-seen syndromes of lung squamous carcinoma are Qi-stagnancy and blood stasis. Small cell lung cancer is more likely to produce phlegm-dampness syndrome while syndrome of Yin-deficiency and blood heat, Qi and Yin-deficiency, Qi-stagnancy and blood stasis are the main syndromes of large cell carcinoma.更多还原