【摘要】 Cronkhite-Canada综合征(CCS)是1955年首次描述的罕见综合征,国内又称之为胃肠道息肉-色素沉着-脱发-指(趾)甲营养不良综合征。该疾病的特征为弥漫性胃肠道息肉、指甲营养不良、脱发、皮肤色素沉着、腹泻、体质量减轻和腹痛。该病的报道以个案居多,诊断主要依靠病史、体格检查、内镜检查以及活检,目前尚无公认的治疗指南。CCS的病因尚不明确,目前无大量证据表明该病有家族性倾向,也尚未排除后代中出现相关症状或患病的可能性。现就郑州大学第一附属医院确诊的2例家族性CCS患者并结合国内外相关文献进行分析探讨。更多还原

【Abstract】 Cronkhite-Canada syndrome(CCS) was a rare syndrome that was first described in 1955. It is also called gastrointestinal polyp-pigmentation-alopecia-nail malnutrition syndrome in China. The disease is characterized by diffuse gastrointestinal polyps, nail malnutrition, alopecia, pigmentation of skin, diarrhea, loss of body mass and abdominal pain. Most of the reported cases of the disease were individual cases. Diagnosis depends mainly on medical history, physical examination, endoscopy and biopsy. At present, there are no accepted guidelines for treatment. The etiology of CCS is unknown. At present, there is no substantial evidence that the disease has a familial predisposition. The possibility of related symptoms or illnesses in offspring has not been ruled out. Now we will analyze and discuss 2 cases of familial CCS diagnosed in the First Affiliated Hospital of Zhengzhou University in combination with relevant literatures at home and abroad.更多还原