节点文献
NADPH氧化酶家族在心血管疾病中作用的研究进展
Research progress in NADPH oxidase family in cardiovascular diseases
【摘要】 烟酰胺腺嘌呤二核苷酸磷酸氧化酶是心血管系统中活性氧(reactive oxygen species,ROS)的主要来源,它包括7种亚型并分别表达在不同的心血管细胞及其细胞器中,参与调节细胞增殖、迁移、分化、凋亡、衰老和炎症反应等多种活动,其衍生的ROS参与高血压、动脉粥样硬化、糖尿病血管病变、心肌梗死后心室重构等多种心血管疾病的病理过程。
【Abstract】 Nicotinamide adenine dinucleotide phosphate oxidase (NOX) is a major source of reactive oxygen species (ROS) in the cardiovascular system. The family of NOX includes seven isoforms, and expressed in different cardiovascular cell types and cell compartments, modulating multiple functions, such as cell proliferation, migration, differentiation, apoptosis, senescence, and inflammatory responses. The NOX-derived ROS are involved in many processes associated with cardiovascular diseases, such as hypertension, atherosclerosis, diabetic vascular disease, ventricular remodeling after myocardial infarction, and so on.
【Key words】 reactive oxygen species; nicotinamide adenine dinucleotide phosphate oxidase; structure; cardiovascular diseases;
- 【文献出处】 中南大学学报(医学版) ,Journal of Central South University(Medical Science) , 编辑部邮箱 ,2019年11期
- 【分类号】R54
- 【被引频次】12
- 【下载频次】852