【摘要】 目的:探讨接受放射治疗的肺癌患者放疗前及不同放射剂量时外周血中TNF-α及INF-γ的变化。方法:对该科收治的30例肺癌放疗患者在放射治疗前、放射治疗2周、4周、6周分别通过ELISA检测外周血中IFN-r、TNF-a的含量。结果:IFN-r的浓度于放疗2000cGy、4000cGy、6000cGy时逐渐升高,F=961.32,P<0.001;TNF-a于放疗2000cGy、4000cGy、6000cGy时逐渐下降,F值为734.85,P值P<0.001。结论:放疗可提高肺癌患者血清中INF-r的水平,降低TNF-a的水平。更多还原

【Abstract】 Objective: Discuss the dynamic changes of TNF-α and INF-γ in peripherd blood of patients with lung cancer before and after different dose radiotherapy. Methods: To detect the content of IFN-r、TNF-a in Peripheral blood of 30 lung cancer radiotherapy patients by ELISA before radiotherapy 1 weeks after radiotherapy, 2 weeks, 4 weeks and 6 weeks. Results: The concentration of IFN-r increased gradually at 2 000 cGy, 4000 cGy and 6000 cGy by radiotherapy. F=961.32, P < 0.001. The concentration of TNF-a decreased gradually at 2 000 cGy, 4000 cGy and 6000 cGy by radiotherapy. The F values were 734.85, respectively, and P values were P < 0.001. Conclusion: Radiotherapy can enhance the level of INF-r with lung cancer patients, and reduce the level of TNF-a.更多还原