【摘要】 目的:探讨OsteoMed M3钉板用于椎管良性肿瘤成形术中的疗效及对应激反应、炎症因子的影响。方法:回顾性2015年1月至2017年6月于我院接受椎管良性肿瘤椎板回植成形术治疗的85例患者临床资料,根据术中固定方式不同分为观察组45例和对照组40例,观察组给予OsteoMed M3钉板内固定椎板回植治疗,对照组给予常规的全椎板切除治疗。比较两组围术期情况、术后应激反应、炎症因子、脊柱功能恢复情况及临床疗效。结果:观察组手术时间、下床活动时间、外支具摘取时间均明显短于对照组,术中出血量明显比对照组少(P<0.05);两组血清超氧化物歧化酶(SOD)、丙二醛(MDA)、肿瘤坏死因子-α(TNF-α)、白介素(IL)-6、IL-8、日本骨科协会评估治疗分数(JOA)评分、脊柱功能障碍指数(NDI)、脊柱Cobb角、椎管宽度在组间、不同时间点、组间·不同时间点的交互作用差异有统计学意义(P<0.05);随访至2018年5月31日时,观察组临床疗效优良率明显高于对照组(P<0.05)。结论:OsteoMed M3钉板用于椎管良性肿瘤椎板回植成形术中的疗效显著,具有术后应激反应、炎症反应小、颈椎功能恢复快等优点,且安全性高,值得应用推广。更多还原

【Abstract】 Objective: To investigate the effect of OsteoMed M3 screw plate on stress response and inflammatory factors in the treatment of benign spinal canal tumors. Methods: From January 2015 to June 2017, 85 patients with benign vertebral canal tumors treated by laminoplasty were retrospectively divided into observation group(45 cases) and control group(40 cases). The observation group was treated with Osteo Med M3 screw plate internal fixation and laminoplasty, while the control group was treated with conventional laminectomy. Cure. The perioperative conditions, post-operative stress response, inflammatory factors, functional recovery of spine and clinical efficacy were compared between the two groups. Results: The operation time, active time and cervical pick up time in the observation group were significantly shorter than those in the control group, and the intraoperative blood loss was significantly less than those in the control group(P<0.05); there were significant differences in the interaction of serum superoxide dismutase(SOD), malondialdehyde(MDA), serum tumor necrosis factor-α(TNF-α), interleukin(IL)-6, IL-8, Japanese Orthopaedic Association Assessment Treatment Score(JOA), spine Dysfunction Index(NDI) score, spine Cobb angle and spinal canal width between groups at inter-group, different time points, inter-group·different time points(P< 0.05); the follow-up until 31 May 2018, the excellent and good rate of clinical efficacy in observation group was significantly higher than those in the control group(P<0.05). Conclusion: OsteoMed M3 nail plate is well forlaminoplasty for benign spinal canal tumors, the postoperative stress response, less inflammatory reaction, fast recovery of cervical function and other advantages, and high safety, it is worthy of application and promotion.更多还原