【摘要】 目的:观察三仁汤与二妙散加减联合西药治疗阴虚夹湿型干眼症的疗效。方法:选取2016年6月至2018年12月本院收治的82例164眼干眼症患者,按照随机数字表分成观察组、对照组各41例82眼,对照组给予玻璃酸钠滴眼液外用,观察组在对照组之上给予三仁汤与二妙散加减方口服,治疗1个月后比较两组中医症候积分及疗效指数、客观指标[泪液分泌试验(SIt)、泪膜破裂时间(BUT)、角膜荧光素染色(FL)]、视觉参数[斯特列尔比(SR)、客观散射指数(OSI)]及临床疗效。结果:治疗1月后,观察组症候积分显著低于对照组(P<0.05),SIt、BUT均显著高于对照组、FL显著低于对照组(P<0.05),SR显著高于对照组、OSI显著低于对照组(P<0.05),且观察组症候积分、SIt、BUT、FL、SR、OSI治疗前后差值均大于对照组(P<0.05);观察组总有效率95.12%,显著高于对照组的74.39%(P<0.05)。结论:三仁汤与二妙散加减联合西药治疗阴虚夹湿型干眼症,可以更好减轻患者中医症候,改善泪膜稳定性及视觉质量,提高临床疗效。更多还原

【Abstract】 Objective:To observe the efficacy of addition and subtraction of Sanren decoction and Ermiao powder combined with western medicine in the treatment of yin deficiency and dampnesstype of xerophthalmia. Methods:82 patients(164 eyes) with xerophthalmia admitted to our hospital from June 2016 to December 2018 were selected. According to the random number table method, the patients were divided into observation group and control group, with 41 cases(82 eyes) in each group. Control group was given sodium hyaluronate eye drops for external use, and observation group was given addition and subtraction of Sanren decoction and Ermiao powder orally on the basis of control group. After 1 month of treatment, the TCM syndromes scores and efficacy index, objective indicators [Schirmer I test(SIt), break-up time(BUT) of tear film, corneal fluorescein staining(FL)], visual parameters [Strehl ratio(SR), objective scatter index(OSI)] and clinical efficacy were compared between the two groups after 1 month of treatment. Results: After 1 month of treatment, the symptoms scores in observation group were significantly lower than those in control group(P<0.05), and the SIt and BUT in observation group were significantly higher than those in control group while the FL was significantly lower than that in control group(P<0.05), and the SR was significantly higher than that in control group while the OSI was significantly lower than that in control group(P<0.05), and the differences of symptoms scores, SIt, BUT, FL, SR and OSI before and after treatment in observation group were greater than those in control group(P<0.05). The total effective rate in observation group was significantly higher than that in control group(95.12% vs 74.39%)(P<0.05). Conclusions:Sanren Decoction and Ermiao Powder combined with western medicine can better alleviate the symptoms of traditional Chinese medicine, improve the stability of tear film and visual quality, and improve the clinical efficacy.更多还原