【摘要】 目的:探讨侵袭性牙周炎患者龈沟液中miR-21表达及与MMP-9水平的相关性。方法:本院侵袭性牙周炎患者89例为病例组,门诊健康体检者78例为对照组;测定两组龈沟液中miR-21、MMP-9水平,并检测菌斑指数、探诊深度、临床附着丧失和出血指数。结果:病例组菌斑指数、探诊深度、临床附着丧失、出血指数均高于对照组,差异有统计学意义(P<0.05);病例组MiR-21mRNA表达水平高于对照组,差异有统计学意义(P<0.05);病例组MMP-9表达水平高于对照组,差异有统计学意义(P<0.05); miRNA-21与菌斑指数、探诊深度、临床附着丧失、出血指数、MMP-9正相关关系明显,差异有统计学意义(P<0.01)。结论:侵袭性牙周炎龈沟液miR-21、MMP-9表达水平密切正相关; miR-21、MMP-9与侵袭性牙周炎组织病变情况密切相关,其在侵袭性牙周炎的发病机制中起着至关重要的作用。更多还原

【Abstract】 Objective: To investigate the miR-21 expression levels in gingival crevicular fluid and its correlation with MMP-9 levels in patients with aggressive periodontitis. Methods: 89 cases of aggressive periodontitis (case group) and 78 cases of health individuals in our hospital (control group) were selected. Then various indicators were detected,including expression levels of microRNA-21 and MMP-9 in gingival crevicular fluid,the plaque index,probing depth,clinical attachment loss and bleeding index. Results: The plaque index,probing depth,clinical attachment loss and bleeding index of the case group were higher than those of the control group (P <0.05); The levels of microRNA-21 and MMP-9 in gingival crevicular fluid of the case group were higher than those of the control group (P <0.05); miRNA-21 was positively correlated with plaque index,probing depth,clinical attachment loss,bleeding index and MMP-9 (P <0.01). Conclusion: The expression levels of microRNA-21 and MMP-9 in gingival crevicular fluid are positively correlated,which play an important role in the pathogenesis of aggressive periodontitis.更多还原