【摘要】 目的分析雄激素受体(androgen receptor,AR)、雌激素受体(estrogen receptor,ER)和促甲状腺激素受体(thyroid-stimulating hormone receptor,TSHR)在甲状腺乳头状癌(papillary thyroid carcinoma,PTC)组织中的表达及相关性,并探讨三者在PTC中的作用及预后判断。方法采用免疫组织化学方法对197例PTC及50例癌旁正常组织和50例甲状腺良性肿瘤组织中AR、ER与TSHR的表达进行检测。结果 PTC组织、PTC旁组织中ER、TSHR阳性表达显著高于良性甲状腺肿瘤组织,AR阳性表达显著低于良性甲状腺肿瘤组织,差异均有统计学意义(P<0.05)。女性ER、TSHR和AR阳性表达高于男性,年龄<45岁者ER阳性表达高于≥45岁者,有包膜浸润者ER、TSHR阳性表达高于无包膜浸润者,肿瘤直径≥4cm者ER、TSHR阳性表达高于肿瘤直径<4cm者,有淋巴结转移者ER、TSHR阳性表达高于无淋巴结转移者,肿瘤分期Ⅲ～Ⅳ者ER、TSHR阳性表达高于肿瘤分期Ⅰ～Ⅱ者,差异均有统计学意义(P<0.05)。ER与TSHR在PTC组织中的蛋白表达水平呈正相关(rs=0.575,P<0.05);ER与AR、AR与TSHR在PTC组织中的蛋白表达水平呈负相关(rs=-0.160,P<0.05;rs=-0.186,P<0.05),但相关性较弱。结论 ER、TSHR二者联合检测有望成为诊断PTC侵袭转移的重要指标。AR可能是一个保护性的因素,PTC中AR高表达提示预后较好。更多还原

【Abstract】 Objective To analyze expression and correlation of androgen receptor(androgen receptor,AR),estrogen receptors(estrogen receptor,ER)and thyroid stimulating hormone receptor(thyroid-stimulating hormone receptor,TSHR)in thyroid papillary carcinoma(papillary thyroid carcinoma,PTC)expression and correlation of organization,The roles of the three factors in PTC and prognosis were also discussed.Methods The expressions of AR,ER and TSHR in 197 cases of PTC,50 cases of paracancer normal tissues and 50 cases of thyroid benign tumors were detected by immunohistochemistry.Results The positive expression of ER and TSHR in PTC tissues and para-PTC tissues were significantly higher than those in benign thyroid neoplasms,and the positive expression of AR was significantly lower than that in benign thyroid neoplasms(P<0.05).The positive rate of ER,TSHR and AR expression in female was higher than that in male.The positive rate of ER expression in patients aged<45 years was higher than that in patients aged≥45 years.The positive expression rates of ER and TSHR in patients with capsule infiltration were higher than those without.The positive rates of ER and TSHR expression in patients with tumor diameter 4 cm were higher than those with tumor diameter<4 cm.The positive rates of ER and TSHR expression in patients with lymph node metastasis were higher than those without lymph node metastasis.Tumor staging Ⅲ-Ⅳ ER and TSHR expression positive rate was higher than the tumor staging Ⅰ-Ⅱ,the differences were statistically significant(P<0.05).There was a positive correlation between ER and TSHR protein expression in PTC tissues(rs=0.575,P<0.05),and a negative correlation between ER and AR,AR and TSHR protein expression in PTC tissues(rs=-0.160,P<0.05,rs=-0.186,P<0.05),but the correlation was weak.Conclusion Combined detection of ER and TSHR is expected to be an important indicator for the diagnosis of PTC invasion and metastasis.AR may be a protective factor,and high expression of AR in PTC indicates a better prognosis.更多还原