【摘要】 目的探讨腰围与胰岛素抵抗的相关性。方法以2008—2017年期间于深圳市南山区人民医院体检中心行健康体检的881例受试者为研究对象,记录性别、年龄及一般情况,收集腰围(WC)、体质量指数(BMI)、收缩压(SBP)、舒张压(DBP)等资料,根据2013年国家卫生与计划生育委员会《中华人民共和国卫生行业标准-成人体重判定》中的中心型肥胖的腰围切点(男性≥90 cm,女性≥85 cm)分为正常腰围组(n=457)和腹型肥胖组(n=424)。全部受试者根据口服葡萄糖耐量试验(OGTT)测定空腹血糖(FBG)、餐后2 h血糖、空腹胰岛素水平,计算胰岛素抵抗指数(HOMA-IR),采用单因素线性回归及多元线性回归法分析腰围与胰岛素抵抗的关系。结果两组受试者间2型糖尿病检出率、性别、年龄、BMI、WC、SBP、DBP、FBG、餐后2 h血糖的水平及胰岛素抵抗程度比较差异均有统计学意义(P<0.05);单因素线性回归分析结果显示,BMI、WC、SBP、DBP、FBG、餐后2 h血糖均与胰岛素抵抗程度密切相关(P<0.05);多元线性回归分析结果显示,WC (β=0.034,95%CI 0.011～0.058)、BMI (β=0.154,95%CI 0.096～0.213)、FBG (β=0.283,95%CI 0.267～0.300)是影响胰岛素抵抗的独立危险因素(P<0.05)。结论腹型肥胖者其胰岛素抵抗程度明显高于正常腰围者,WC是影响胰岛素抵抗的危险因素。更多还原

【Abstract】 Objective To explore the correlation between waist circumference and insulin resistance.Methods A total of 881 patients who underwent physical examination in the physical examination center, the People’s Hospital of Nanshan District of Shenzhen from 2008 to 2017 were selected as study subjects. The data were collected,such as gender, age, general information, waist circumference(WC), body mass index(BMI), systolic blood pressure(SBP), and diastolic blood pressure(DBP). According to the waist circumference point of the middle-central obesity(≥90 cm for males, ≥85 cm for females) in"the Health Industry Standard of the People’s Republic of China-Adult Weight Determination"issued by the National Health and Family Planning Commission in 2013, the patients were divided into the normal waist group(n=457) and the abdominal obesity group(n=424). Fasting blood glucose(FBG), 2 h postprandial blood glucose levels were measured according to oral glucose tolerance test(OGTT), and insulin resistance index(HOMA-IR) was calculated. The relationship between waist circumference and insulin resistance was analyzed by single factor linear regression and multiple linear regression. Results There were significant differences in the detection rate of type 2 diabetes, gender, age, BMI, waist circumference, SBP, DBP, FBG, postprandial 2-hour blood glucose, and insulin resistance between the two groups(P<0.05). Single factor linear regression analysis showed that BMI, waist circumference, SBP, DBP, FBG, 2 h postprandial blood glucose were all correlated with the degree of insulin resistance(P<0.05). Multiple linear regression showed that waist circumference(β=0.034, 95%CI 0.011-0.058) and BMI(β=0.154,95%CI 0.096-0.213), FBG( β =0.283, 95% CI 0.267-0.300) were independent risk factors for insulin resistance(P<0.05). Conclusion The degree of insulin resistance in subjects with abdominal obesity is significantly higher than that in individuals with normal waist circumference. Waist circumference is a risk factor for insulin resistance.更多还原