【摘要】 目的探讨间苯三酚在体外受精(IVF)-胚胎移植(ET)中的应用效果。方法将首次行IVF-ET的130例患者随机分为对照组及观察组,每组65例。两组均接受黄体支持用药,观察组同时给予间苯三酚治疗。比较两组的IVF基础情况、妊娠结局、新生儿畸形率及药物不良反应发生情况。结果两组的IVF基础情况比较,差异均无统计学意义(均P> 0. 05)。观察组的生化妊娠率、临床妊娠率、胚胎着床率及活产率均高于对照组(均P <0. 05),但两组的异位妊娠率、多胎率及流产率比较,差异均无统计学意义(均P> 0. 05)。两组均未观察到药物不良反应及新生儿缺陷。结论间苯三酚可以改善行IVF-ET患者的妊娠结局,其安全性较好。更多还原

【Abstract】 Objective To explore the efficacy of phloroglucinol applied to in vitro fertilization( IVF) and embryo transfer( ET). Methods A total of 130 patients undergoing the first IVF-ET were randomly divided into the control group or observation group,with 65 patients in each group. Luteal support was conducted in both group,and the observation group was additionally administered with phloroglucinol. The basic data of IVF,pregnant outcome,neonatal malformation rate and incidence of adverse drug reactions were compared between the two groups. Results There were no significant differences in the basic data of IVF between the two groups( P > 0. 05). The biochemical pregnancy rate,clinical pregnancy rate,embryo implantation rate and live birth rate in the observation group were higher than those in the control group( all P < 0. 05),but there were no significant differences in the multiple pregnancy rate or abortion rate between the two groups( all P > 0. 05). No adverse drug reactions or birth defects were observed in either group. Conclusion Phloroglucinol can improve the pregnant outcome of the patients receiving IVF-ET,and is relatively safe.更多还原