【摘要】 目的探讨康柏西普治疗病理性近视脉络膜新生血管的临床效果。方法本研究对象选自我院2016年1月～2018年12月治疗的80例病理性近视脉络膜新生血管患者。采用国际随机字母表法将80例患者分成实验组和対照组,各40例,对照组采取保守治疗方法,实验组给予玻璃体腔内注射康柏西普治疗,对治疗前后眼内压(IOP)、CNV面积和血清C反应蛋白(CRP)水平等变化进行对比,观察比较治疗前后最佳矫正视力(BCVA)和黄斑区视网膜厚度(CMT)变化及不良反应发生情况。结果治疗后IOP、CNV面积和CRP均明显下降,实验组低于对照组,差异有统计学意义(P <0.05);治疗后,两组患者BCVA明显升高,CMT明显降低,较治疗前相比,差异有统计学意义(P <0.05),且实验组患者BCVA高于对照组,CMT明显低于对照组,差异有统计学意义(P<0.05);随访3个月期间,两组不良反应差异无统计学意义(P>0.05)。结论康柏西普治疗病理性近视脉络膜新生血管的临床效果显著,有助于提高患者视力,减少黄斑区视网膜厚度,且不良反应少,值得在临床中推广应用。更多还原

【Abstract】 Objective To explore clinical curative effects of conbercept in treatment of pathological myopic choroidal neovascularization. Methods 80 patients with pathological myopic choroidal neovascularization who were treated in our hospital from January 2016 to December 2018 were selected as research objects. They were divided into experimental group and control group by international random alphabet method, with 40 cases in each group. The control group was given conservative treatment while the experimental group was given intravitreal injection of conbercept. Intraocular pressure(IOP), CNV area and serum C-reactive protein(CRP) levels before and after treatment were compared. Changes of best corrected visual acuity(BCVA) and macular retinal thickness(CMT) before and after treatment and the occurrence of adverse reactions were observed. Results After treatment, IOP, CNV area and CRP decreased significantly, and those of the experimental group was lower than the control group. The differences were statistically significant(P < 0.05). After treatment, BCVA was significantly increased in both groups, and CMT was significantly reduced. Compared with those before treatment, the difference was statistically significant(P < 0.05). The BCVA of the experimental group was higher than that of the control group, and the CMT was significantly lower than that of the control group. The difference was statistically significant(P < 0.05). During the follow-up period of 3 months, there was no significant difference in adverse reactions between the two groups, and the difference was not statistically significant(P > 0.05). Conclusion Conbercept in treatment of pathological myopic choroidal neovascularization has significant clinical curative effects, which helps to improve visual acuity of patients and reduce macular retinal thickness. It has few adverse actions, which is worthy of clinical promotion and application.更多还原