【摘要】 目的:探讨梅州市客家人群IgA肾病(IgAN)的临床表现和病理特征,并分析两者之间的相关性。方法:回顾性分析2012年1月至2018年8月广东省梅州市人民医院收治的157例梅州市客家IgAN患者的临床资料,根据Lee分级标准的不同将患者分为A组[轻度损害(Ⅰ～Ⅱ级),79例)]和B组[中重度损害(Ⅲ～Ⅴ级),78例]。对比两组患者的临床资料和病理特点,并分析两者之间的关系。结果:两组患者临床表现以蛋白尿(96.8%)为主,病理改变则以Ⅰ级和Ⅱ级病变较常见(24.8%、25.5%)。肾功能与病理分级关系分析显示,内生肌酐清除率(Ccr)<60 mL/min的患者中Lee分级Ⅰ～Ⅴ级比例分别为3.2%、10.2%、10.2%、15.9%、11.5%。结论:IgAN患者随着Lee病理等级的升高,肾脏损害相应加重,故应对轻微尿异常无症状患者或其他临床表现类型疑似患者及时进行肾活检,以达到早发现、早治疗的目的。更多还原

【Abstract】 Objective:To investigate the association between clinical manifestations and pathological features of Hakka patients with IgA nephropathy(IgAN) in Meizhou.Methods:The clinical data from 157 Hakka patients with IgAN in Meizhou from January 2012 to August 2018 were retrospectively analyzed.The patients were divided into group A(79 cases,mild impairment,clinical stageⅠand Ⅱ) and group B(78 cases,moderate-severe impairment,clinical stage Ⅲ to Ⅴ).The clinical and pathologic characteristics were collected and analyzed.Results:Proteinuria was the major clinical manifestation(96.8%),and stageⅠandⅡ(24.8%,25.5%) were common pathological changes.However,nearly none of those immune globulins was observed in glomerular capillary wall or basilar membrane.Pathology Lee grade I to Ⅴ in patients with Ccr <60 mL/min account for 3.2%,10.2%,10.2%,15.9% and 11.5% respectively.Conclusion:The degree of kidney damage increased with an increase in Lee grade in IgAN patients.Renal biopsies should be performed in time for early detection and early treatment in asymptomatic patients with mild abnormal urine or suspected patients with other clinical manifestations.更多还原