【摘要】 目的探讨阿司匹林肠溶片联合盐酸拉贝洛尔治疗妊娠期高血压的临床疗效。方法选取2016年5月—2018年8月于凉山州第一人民医院收治的妊娠期高血压患者240例作为研究对象,随机将患者分为对照组和治疗组,每组各120例。对照组患者静脉滴注盐酸拉贝洛尔注射液,50 mg溶于5%葡萄糖注射液250 m L中,充分混合,维持剂量为2 mg/min。当血压控制良好并且低于140/90mm Hg时患者口服盐酸拉贝洛尔片,100mg/次,3次/d。治疗组患者在对照组治疗的基础上口服阿司匹林肠溶片,50 mg/d,1次/d。两组患者持续治疗到妊娠前1 d停用。观察两组患者的临床疗效,同时比较两组治疗前后的血压和妊娠结局。结果治疗后,对照组和治疗组的总有效率分别为80.83%、96.67%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者的收缩压和舒张压均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗后治疗组血压低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组胎儿存活率分别为93.33%、100.00%,两组比较差异具有统计学意义(P<0.05)。结论阿司匹林肠溶片联合盐酸拉贝洛尔治疗妊娠期高血压具有较好的临床疗效,可改善患者血压和妊娠结局,值得临床推广使用。更多还原

【Abstract】 Objective To investigate the clinical efficacy of Aspirin Enteric-coated Tablets combined with labetalol hydrochloride in treatment of gestational hypertension. Methods Patients(240 cases) with gestational hypertension in the First People’s Hospital of Liangshan Prefecture from May 2016 to August 2018 were randomly divided into control and treatment groups, and each group had 120 cases. Patients in the control group were iv administered with Labetalol Hydrochloride Injection, 50 mg added into 5% glucose injection 250 mL, and maintenance dose was 2 mg/min. And patients were po administered with Labetalol Hydrochloride Tablets, 100 mg/time, three times daily, when blood pressure was well controlled and lower than 140/90 mmHg. Patients in the treatment group were po administered with Aspirin Enteric-coated Tablets, 50 mg/d, once daily. Patients in two groups were discontinued 1 d before pregnancy. After treatment, the clinical efficacies were evaluated, the blood pressure and pregnancy outcome in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.83% and 96.67%, respectively, and there was difference between two groups(P < 0.05). After treatment, the systolic and diastolic blood pressures in two groups were significantly decreased, and the difference was statistically significant in the same group(P < 0.05). And blood pressures in the treatment group after treatment were significantly lower than those in the control group, with significant difference between two groups(P < 0.05). After treatment, the livability in the control and treatment groups were 93.33% and 100.00%, respectively, and there was difference between two groups(P < 0.05). Conclusion Aspirin Enteric-coated Tablets combined with labetalol hydrochloride has clinical curative effect in treatment of gestational hypertension, can improve the blood pressure and pregnancy outcome of patients, which has a certain clinical application value.更多还原