【摘要】 目的分析不同长短未治疗期(DUP)首发精神分裂症患者同型半胱氨酸(HCY)与IL-6及中性粒-淋细胞比率(NLR)临床表达差异性。方法选取2012年4月～2015年10月间在本院接受治疗首次DUP患者162例,长DUP组87例,短DUP组75例;全自动血细胞分析仪检测血清淋巴细胞计数(LYM)、白细胞计数(WBC)、中性粒细胞计数(NEU)、淋巴细胞百分比(LYM%)、血红蛋白(HGB)、中性粒细胞百分比(NEU%)及红细胞比容(HCT)等。结果短CUP组与长DUP组患者在婚姻状况方面对比差异有统计学意义(P<0.05);短DUP患者血清IL-6、HCY、NLR及PANSS评分均低于长DUP患者,差异有统计学意义(P<0.05);Pearson相关分析显示,DUP和血清NLR、IL-6、HCY及PANSS评分为正相关关系(r=0.351、0.786、0.402、0.908,P=0.010、0.001、0.003、0.001);PANSS评分和血清HCY、IL-6为正相关关系(r=0.472、0.783,P=0.001、0.001);Logistic回归分析显示,血清IL-6为影响DUP独立危险因素。结论短DUP与长DUP患者在精神病理学症状方面存在差异,血清NLR、IL-6及HCY可当做判别精神分裂症患者病情程度参考指标。更多还原

【Abstract】 Objective Analysis of clinical manifestations of HCY,IL-6 and NLR in patients with first-episode schizophrenia with different lengths of treatment. Methods 162 patients with first DUP were treated in our hospital from April 2012 to October 2015,87 patients in the long DUP group and 75 patients in the short DUP group. Automated blood cell analyzer for serum lymphocyte count(LYM),white blood cell count(WBC),neutrophil count(NEU),percentage of lymphocytes(LYM%),hemoglobin(HGB),and percentage of neutrophils(NEU%)and hematocrit(HCT). Results There were significant differences in marital status between the short CUP group and the long DUP group(P<0.05). The serum IL-6,HCY,NLR and PANSS scores of patients with short DUP were lower than those of long DUP patients. The difference was statistically significant(P<0.05). Pearson correlation analysis showed that DUP was positively correlated with serum NLR,IL-6,HCY,and PANSS scores(r=0.351,0.786,0.402,0.908,P=0.010,0.001,0.003,0.001). PANSS score and serum HCY IL-6 was positively correlated(r=0.472,0.783,P=0.001,0.001). Logistic regression analysis showed that serum IL-6 was an independent risk factor for DUP. Conclusions There are differences in psychopathological symptoms between patients with short DUP and long DUP. Serum NLR,IL-6 and HCY can be used as reference indicators for judging the severity of schizophrenia.更多还原