【摘要】 目的探讨首发和复发抑郁症患者抗抑郁药物治疗前后认知功能特点及其与临床症状严重程度的关系。方法分别选取58例首发和复发患者以及39例正常对照,采用HAMA、HAMD及RBANS分别评定症状的严重程度及认知功能。结果①首发组、复发组以及正常对照组三组在治疗前RBANS各因子分及总分差异有统计学意义(P<0.05);首发组及复发组的RBANS各因子及RBANS总分均低于正常对照组,首发组各因子及RBANS总分均高于复发组,差异有统计学意义(P<0.05)。②治疗8周后三组间在即刻记忆、注意力、延时记忆及RBANS总分差异均有统计学意义(P<0.05);首发组及复发组的即刻记忆、延迟记忆及RBANS总分均低于正常对照组,首发组的各因子及RBANS总分均高于复发组,差异均有统计学意义(P<0.05)。③治疗前后两组HAMA总分、HAMD总分、RBANS各因子分及总分均有显著性改变,差异有统计学意义(P<0.05)。④HAMD、HAMA部分因子分及总分与RBANS部分因子分及总分呈负相关(P<0.05)。结论首发和复发抑郁症患者不仅有情绪症状,也有广泛的认知损害,且复发患者认知损害更严重;抗抑郁药能缓解患者抑郁症状且能改善患者的认知功能;抑郁症的认知功能损害与症状严重度呈相关性。更多还原

【Abstract】 Objective To explore the relationship between cognitive function and severity of clinical symptoms in patients with first-episode and recurrent depression before and after treatment with antidepressant drugs. Methods 58 patients with first and recurrent depression and 39 normal controls were selected,and the severity and cognitive function of the symptoms were assessed by HAMA,HAMD and RBANS,respectively. Results ① There were significant differences in the factors and total scores of RBANS between the first group,the recurrent group and the normal control group(P<0.05). The RBANS factors and total RBANS scores of the first-episode group and the relapse group were lower than those of the normal control group. The factors and total RBANS scores of the first-episode group were higher than those of the relapse group,and the difference was statistically significant.(P<0.05). ② After 8 weeks of treatment,there were significant differences in immediate memory,attention,time-delay memory and RBANS scores among the three groups(P<0.05). The immediate and delayed memory and the total score of RBANS were lower in the first and recurrent groups. In the normal control group,the total scores of the factors and RBANS in the first group were higher than those in the recurrence group,and the difference was statistically significant(P<0.05). ③ Before and after treatment,the total scores of HAMA,total score of HAMD,scores of RBANS and total scores were significantly different(P<0.05). ④ HAMD and HAMA partial factor scores and total scores were negatively correlated with RBANS partial factor scores and total scores(P<0.05). Conclusion Patients with first-episode and recurrent depression not only have emotional symptoms,but also extensive cognitive impairment,and cognitive impairment is more serious in patients with relapse;antidepressants can alleviate depressive symptoms and improve cognitive function;cognitive function of depression The damage is related to the severity of the symptoms.更多还原