【摘要】 目的探讨艾司奧美拉唑联合康复新液对胃溃疡出血患者的溃疡黏膜愈合质量的影响。方法选取2017年3月至2018年8月在涟水县人民医院接受治疗的94例胃溃疡出血患者作为研究对象。采用随机数字表法随机分为对照组和观察组,每组47例,对照组给予艾司奥美拉唑镁肠溶片治疗,观察组给予艾司奥美拉唑肠溶片联合康复新液治疗,总疗程为4周。分析两组的短期止血效果、胃镜下溃疡愈合情况、胃小凹和微血管形态改善情况、再生黏膜组织学成熟度。结果观察组的止血时间短于对照组,总有效率和止血率高于对照组,差异均有统计学意义(P均<0.05)。观察组的胃镜下溃疡愈合率高于对照组,两组的胃小凹形态均有改善,且观察组A型和B型胃小凹占比以及微血管网规则者占比均明显高于对照组,差异均有统计学意义(P均<0.05)。对再生黏膜组织学成熟度分析显示,观察组的胶原纤维沉积面积、Ⅰ型/Ⅲ型胶原蛋白比值、羟脯氨酸含量均显著高于对照组,差异均有统计学意义(P均<0.05)。结论艾司奧美拉唑联合康复新液治疗胃溃疡出血的效果确切,其短期止血效果和溃疡愈合情况均明显优于艾司奧美拉唑单药治疗,并且能明显改善胃小凹和微血管形态,提高再生黏膜组织学成熟度。更多还原

【Abstract】 Objective An attempt was made in this paper to investigate the effect of Esmeprazole combined with Kangfuxin solution on gastric ulcer mucosa healing in patients with gastric ulcer bleeding. Methods Ninety-four patients with gastric ulcer bleeding who were treated in People′s Hospital of Lianshui County from March 2017 to August 2018 were selected as the research subjects and randomly divided into the control group and the observation group, with 47 cases in each group. The control group was treated with Ezomeprazole enteric-coated tablets while the observation group was treated with Ezomeprazole enteric-coated tablets combined with Kangfuxin solution for 4 weeks. The short-term hemostatic effect, healing of ulcers under gastroscopy, improvement of gastric pits and microvascular morphology, and histological maturity of regenerating mucosa were analyzed. Results The hemostatic time of the observation group was shorter than that of the control group, and the total effective rate and hemostatic rate were higher than those of the control group. Besides, there were significant differences between the two groups(all P<0.05). In addition, the gastroscopic ulcer healing rate in the observation group was higher than that in the control group, and the gastric pit shape of both groups was improved. Moreover, the proportions of type A and B type gastric pits, and the proportion of regular microvascular network in the observation group were significantly higher than those in the control group, and the differences are statistically significant(all P<0.05). Furthermore, the analysis of the histological maturity of regenerative mucosa showed that the collagen fiber deposition area, type Ⅰ/type Ⅲ collagen ratio, and hydroxyproline content in the observation group were significantly higher than those in the control group, and the differences were statistically significant(all P<0.05). Conclusions The effect of Esmeprazole combined with Kangfuxin solution on gastric ulcer bleeding is significant, and its short-term hemostatic effect and ulcer healing are significantly better than Esmeprazole monotherapy, and can significantly improve the gastric pits and microvascular morphology, and improve the histological maturity of regenerating mucosa.更多还原