【摘要】 目的探讨柳州地区儿童慢性咳嗽的常见病因及其影响因素。方法选择2015年1月—2016年12月在柳州市妇幼保健院就诊的儿童咳嗽患者。按照《儿童慢性咳嗽诊断和治疗指南(2013年修订)》的诊断流程对390例慢性咳嗽患儿进行病因学分析。结果儿童慢性咳嗽的前三位病因依次为咳嗽变异性哮喘(cough variant asthma,CVA)、呼吸道感染后咳嗽(post-infectious cough,PIC)、上气道咳嗽综合征(upper airway cough syndrome,UACS)。CVA的影响因素:女童是发生CVA的保护因素(OR 95%CI:0.647(0.101～0.917);家族支气管哮喘病史、家族变应性鼻炎病史、父母有吸烟史、气候改变是CVA的危险因素,其OR 95%CI分别为:1.055(1.017～2.481)、1.170(1.084～1.492)、1.092(1.038～1.204)、20.904(9.233～52.087)。PIC的影响因素:居住环境潮湿[OR 95%CI:1.825(1.124～1.977)]。UACS的危险因素包括:家族变应性鼻炎病史、居住环境潮湿、居住环境有饲养宠物、居住环境种植花草、父母吸烟5个因素,其OR 95%CI分别为:1.238(1.093～1.615)、1.332(1.136～1.814)、1.265(1.088～1.802)、7.120(6.009～8.145)、11.855(9.771～14.215)。结论儿童慢性咳嗽的病因繁多,CVA、PIC和UACS是儿童慢性咳嗽的主要病因。儿童性别、过敏史情况、家庭居住环境、父母吸烟情况和气候改变是儿童慢性咳嗽的主要影响因素。更多还原

【Abstract】 Objective To explore the common causes and influencing factors of chronic cough in children in Liuzhou area.Methods Children with chronic cough who were received treatment in the otorhinolaryngology clinic of Liuzhou maternal and child health hospital from January 2015 to December 2016 were enrolled.According to the cli-nical diagnosis flow of the 2013 Guidelines of diagnosis and treatment of chronic cough in children,390 cases with chronic cough were collected for etiological diagnosis.Results The top three causes of chronic cough in children were cough variant asthma(CVA),respiratory tract infection cough(PIC),upper airway cough syndrome(UACS).The results of multivariate logistic regression analysis showed that,Influencing factors of CVA:girl was a protective factor for CVA(OR:0.647,95% CI:(0.101～0.917));family history of bronchial asthma,family history of allergic rhinitis,parental smoking,climate change were risk factors for CVA,the OR and 95% CI were 1.055(1.017～2.481),1.170(1.084～1.492),1.092(1.038～1.204)and 20.904(9.233～52.087),respectively.Risk factors for PIC:dwelling environment was moist(OR:1.825;95% CI:(1.124～1.977)).The risk factors for UACS included:family history of allergic rhinitis,wet living environment,living environment with pets,living environment for gro-wing flowers and plants,and parents smoking.The OR and 95% CI were 1.238(1.093～1.615),1.332(1.136～1.814),1.265(1.088～1.802),7.120(6.009～8.145)and 11.855(9.771～14.215),respectively.Conclusion The causes of chronic cough in children are numerous.The results show that CVA,PIC and UACS are the main causes of chronic cough in children.Child gender,allergy history,family living environment,parental smoking status and climate change are the main influencing factors of chronic cough in children.更多还原