【摘要】 目的探讨血清抗缪勒管激素(AMH)检测在多囊卵巢综合征(PCOS)诊断中的应用价值。方法选取2017年1月至2018年6月经临床诊断为多囊卵巢综合征患者206例,简称为研究组;其中雄性激素睾酮(T)浓度≤75ng/dL患者130例,简称为研究组A;雄性激素睾酮(T)浓度>75ng/dL患者76例,简称为研究组B。同期在健康管理中心招募206例女性为对照组,利用统计学软件分析多囊卵巢综合征患者和健康人群的AMH检测结果。结果研究组AMH浓度明显高于对照组,研究组B的AMH浓度明显高于研究组A,差异均有统计学意义(P<0.05);研究组AMH浓度与睾酮浓度呈正相关性,相关系数r=0.171且P<0.05;ROC曲线分析AMH诊断PCOS患者的线下面积为0.776,面积标准误为0.028,差异有统计学意义(P=0.000),以AMH浓度6.19ng/mL为PCOS诊断界值时,灵敏度为69%,特异度为71%。结论多囊卵巢综合征患者血清中AMH浓度显著升高,血清AMH浓度检测对多囊卵巢综合征的临床诊断有一定价值。更多还原

【Abstract】 Objective To explore the application value of serum anti-Müllerian hormone(AMH)detection in polycystic ovarian syndrome(PCOS).Methods 206 patients with polycystic ovarian syndrome who were diagnosed as PCOS from January 2017 to June 2018 were selected as the study group.Among them,130 patients with testosterone(T)concentration≤75 ng/dL were named as study group A,and 76 patients with testosterone(T)concentration>75 ng/dL were named as study group B.In the same period,206 women were recruited in the health management center as the control group.The AMH detection results of patients with polycystic ovarian syndrome and healthy people were analyzed by statistical software.Results The AMH concentration in the study group was significantly higher than that in the control group,and the AMH concentration in the study group B was significantly higher than that in the study group A,and the differences were statistically significant(P<0.05).The AMH concentration in the study group was positively correlated with the testosterone concentration,and the correlation coefficient r was 0.171,and P<0.05.ROC curve analysis showed that the area under ROC curve of AMH diagnosis of PCOS patients was 0.776,area standard error was 0.028,and the difference was significant(P=0.000).When AMH concentration of 6.19 ng/mL was taken as PCOS diagnostic cut-off value,the sensitivity was 69%,and the specificity was 71%.Conclusion The serum AMH concentration in patients with PCOS was significantly increased,and the detection of AMH in serum has certain value in the clinical diagnosis of polycystic ovarian syndrome.更多还原