【摘要】 目的探讨特布他林与布地奈德（T&B）压缩雾化吸入治疗老年慢性阻塞性肺疾病（COPD）急性加重期患者的临床效果。方法 80例急性加重期COPD （AECOPD）老年患者,分为对照组与观察组各40例,对照组接受常规治疗,观察组在对照组治疗基础上联合压缩雾化吸入T&B,对比两组的临床疗效、临床症状体征的改善时间及肺功能指标在治疗前后的变化。结果观察组的完全缓解率及总有效率高于对照组,差异均具有统计学意义（P <0. 05）。观察组的气促缓解、喘鸣音消失、咳嗽消失时间均低于对照组,差异均具有统计学意义（P <0. 05）。两组治疗前的1秒用力呼气容积（FEV₁）、FEV₁与用力肺活量（FVC）比值（FEV₁/FVC）比较差异均无统计学意义（P> 0. 05）;两组患者治疗后的FEV₁、FEV₁/FVC均高于同组治疗前,差异均具有统计学意义（P <0. 05）;观察组治疗后的FEV₁、FEV₁/FVC均高于对照组,差异均具有统计学意义（P <0. 05）。结论特布他林与布地奈德压缩雾化吸入对于老年COPD急性加重期患者的治疗效果明显,能够有效改善其临床症状和体征,控制其急性病情,同时加强了肺功能,可在临床推广应用。更多还原

【Abstract】 Objective To analyze clinical effect of aerosol inhalation of terbutaline and budesonide in the treatment of acute exacerbations of chronic obstructive pulmonary disease（ AECOPD）. Methods 80 older patients with AECOPD were divided into the control group（ 40 cases） and the observation group（ 40 cases）. The control group received the routine treatment. The observation group received aerosol inhalation of terbutaline and budesonide. The clinical symptoms and signs and pulmonary function were documented. Results The complete remission rate and overall response rate in the observation group were higher than those in the control group（ P < 0. 05）. The time of dyspnea relief,wheezing sound disappearance and cough disappearance in the observation group were shorter than those in the control group（ P < 0. 05）. There were no significant differences in FEV₁ and FEV₁/FVC between the two groups before treatment（ P > 0. 05）. FEV₁ and FEV₁/FVC increased significantly in the two groups after treatment（ P < 0. 05）.FEV₁ and FEV₁/FVC in the observation group were higher than those in the control group（ P < 0. 05）. Conclusion Aerosol inhalation of terbutaline and budesonide exhibits obvious therapeutic effect for older patients with AECOPD,which can effectively improve the clinical symptoms and signs and lung function.更多还原