【摘要】 层状双氢氧化物LDH作为拥有特殊层状结构的纳米药物载体,具有低毒性、可降解性以及药物缓释的性能。因此,设计合成了具有可降解的低毒性靶向药物缓释系统LDH/HA-PEG/5-FU。为了使药物递送系统LDH/HA-PEG/5-FU获得最大载药量,采用控制变量法测定了在不同的反应时间、反应温度以及不同的HA-PEG投放浓度下LDH/HA-PEG/5-FU的药物包封率、zeta电位及粒径,最终得出一步法合成LDH/HA-PEG/5-FU的最优反应条件为,恒温水浴70℃,反应时间24 h,加入浓度为1 mg/mL的HA-PEG分散液,在上述条件下合成的药物递送体系LDH/HA-PEG/5-FU可获得最高载药量。更多还原

【Abstract】 The layered double hydroxide LDH is one kind of nano drug carriers which have special layered structure, low toxicity, degradability and sustained drug release property. In our study, a low toxicity targeted drug release system LDH/HA-PEG/5-FU with fine degradability was synthesized. In order to obtain the maximum drug loading for the system LDH/HA-PEG/5-FU, the control variable method was used to detect the encapsulation efficiency, zeta potential and particle size of LDH/HA-PEG/5-FU at different reaction times, different reaction temperatures and different concentrations of HA-PEG. Finally, the optimal reaction condition for one-method synthesis of LDH/HA-PEG/5-FU was obtained: thermostatic waterbath of 70 ℃, 24 h of reaction time and 1 mg/mL of the concentration of HA-PEG. The drug delivery system of LDH/HA-PEG/5-FU synthesized under the above conditions was able to obtain the maximum drug loading.更多还原