【摘要】 Janus激酶(Janus kinase, JAK)/信号转导子和转录活化子(signal transducer and activator of transcription,STAT)信号通路是细胞因子信号传导的下游通路,调控细胞的发育、分化、增殖、凋亡等,不仅参与调节正常的生理过程,在肿瘤的发生发展中也起着重要作用,尤其是在血液系统肿瘤中意义重大。近年来,随着对JAK/STAT信号通路研究的深入,人们发现该通路在实体肿瘤的发生发展中也扮演关键角色。本文就近年来JAK/STAT信号通路参与肺癌发生发展、肺癌转移、肺癌耐药机制形成以及靶向该通路的抑制剂在肺癌治疗中的应用现状进行综述。更多还原

【Abstract】 Janus kinase(JAK)/signal transducer and activator of transcription(STAT) signaling pathway is one of the downstream pathways of cytokine signaling transduction. It regulates cell development, differentiation, proliferation, apoptosis and so on. The pathway is not only involved in the regulation of normal physiological processes, but also significant in the development of tumors, especially in hematologic malignancies. In recent years, with the further research of JAK/STAT signaling pathway, it has been found that the pathway also plays a key role in the development of solid tumors. Here we reviewed the research advances of JAK/STAT signaling pathway in lung cancer, especially the mechanisms of development, metastasis and drug resistance, and the application of inhibitors which targeting JAK/STAT signaling pathway in the treatment of lung cancer.更多还原