【摘要】 目的观察重复低频经颅磁刺激联合阿戈美拉汀对老年抑郁症患者临床疗效。方法选择2016年10月至2017年6月河北省第六人民医院老年抑郁症92例患者,中途退出7例,最终纳入患者85例,按照随机抽签的方式分为对照组40例,观察组45例,2组患者均给予阿戈美拉汀片口服,在此基础上观察组加用重复低频经颅磁刺激治疗,观察治疗4、8周后2组患者血清5-羟色胺(5-HT)、去甲肾上腺素(NE)表达水平及汉密尔顿抑郁量表评分。结果治疗前2组患者血清5-HT、NE表达水平及汉密尔顿抑郁量表评分比较,差异无统计学意义(P>0. 05)。治疗4、8周后2组患者血清5-HT、NE水平比较差异无统计学意义(P>0. 05);但观察组患者汉密尔顿抑郁量表评分较对照组降低(P<0. 05)。治疗8周后观察组总有效率明显高于对照组(88. 89%vs 72. 50%,P<0. 05)。结论重复低频经颅磁刺激联合阿戈美拉汀治疗老年抑郁症能显著改善患者的临床症状,临床疗效好,治愈率高,易于操作,值得临床推广。更多还原

【Abstract】 Objective To observe the effect of repeatedlow frequency transcranial magnetic stimulation combined with agomelatine on serum 5-hydroxytryptamine( 5-HT) and norepinephrine( NE) levels in elderly patients with depression,and evaluate its clinical efficacy. Methods From October 2016 to June 2017,85 elderly patients with depression in the Sixth People’s Hospital of Hebei Province were randomly divided into control group( n = 40) and observation group( n = 45). Both groups were given agomelatine. The observation group was treated with repeated low frequency transcranial magnetic stimulation. The levels of 5-HT and NE and the depression scale of Hamilton Depression Scale in the two groups were observed after 4 and 8 weeks of treatment. Results There was no significant difference in serum 5-HT and NE expression level before treatment and HAMD in Hamilton Depression Scale( P>0. 05). After 4 and 8 weeks of treatment,there was no significant difference in serum 5-HT and NE levels between the two groups( P>0. 05). The Hamilton Depression Rating Scale depression score in the observation group was lower than that in the control group( P < 0. 05).Conclusion Repeated low frequency transcranial magnetic stimulation has no significant effect on serum 5-HT and NE levels in elderly patients with depression. Combined with agomelatine can significantly reduce depression in the Hamilton Depression Rating Scale in elderly patients and improve clinical symptoms of depression,the quality of life,no obvious adverse reactions.更多还原