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基于互模式熵的DNA序列相似性分析
DNA sequence similarity analysis based on mutual pattern entropy
【摘要】 随着基因组计划的开展,DNA序列相似性分析成了现代生物学研究不可缺的一部分。本研究以H5N1、H1N1和H2N2等7种病毒的DNA序列作为研究对象,使用整数法将DNA序列编码成时间序列信息,计算时间序列之间的互模式熵(Mutual Mode Entropy,MME)。分析不同DNA序列的MME对序列相似性的表达准确性。实验表明通过整数表示方法的DNA序列的M M E能够定性地解释7种DNA序列之间的相似性关系。
【Abstract】 With the development of the genome project,DNA sequence similarity analysis has become an indispensable part of modern biological research. In this study,DNA sequences of seven viruses,such as H5 N1,H1 N1 and H2 N2,were used as research objects,and DNA sequences were encoded into time series information using an integer method,Calculate Mutual Mode Entropy( MME) between time series. The accuracy of expression of sequence similarity by MME of different DNA sequences was analyzed.Experiments have shown that the MME of the DNA sequence by the integer representation method can qualitatively explain the similarity relationship between the seven DNA sequences.
【Key words】 similarity analysis; DNA sequence; DNA representation; mutual mode entropy;
- 【文献出处】 智能计算机与应用 ,Intelligent Computer and Applications , 编辑部邮箱 ,2019年06期
- 【分类号】Q811.4;O211.61
- 【下载频次】104