【摘要】 目的分析血清脂蛋白相关磷脂酶A2(Lp-PLA2)在心房颤动(简称房颤)并心力衰竭(简称心衰)患者体内的表达及其临床价值。方法选取2017年1-12月在该院住院的房颤并心衰患者100例为研究对象,同时选择房颤无心衰、无房颤和心衰的住院患者各50例为对照。对所有患者的血清中氨基末端脑钠肽前体(NT-proBNP)、脂蛋白相关磷脂酶A2(Lp-PLA2)水平进行检测,并行超声心动图及心电图检查。结果 A组患者血清中Lp-PLA2、NT-proBNP水平最高,B组最低,3组比较差异有统计学意义(P<0.05)。A组患者LVEF水平最低,B组最高,3组比较差异有统计学意义(P<0.05)。房颤并心衰患者Lp-PLA2与NTproBNP呈正相关(P<0.05),与左心室射血分数(LVEF)呈负相关(P<0.05),Lp-PLA2水平越高,心脏功能越差。结论在房颤并心衰患者中Lp-PLA2水平可较好地反映心功能。更多还原

【Abstract】 Objective To analyze the expression and clinical value of serum Lp-PLA2 in the patients with atrial fibrillation(AF)complicating heart failure.Methods One hundred cases of AF complicating heart failure in the cardiology department of this hospital from January 2017 to December 2017 were selected(group A),meanwhile 50 inpatients with AF without heart failure(group B)and 50 inpatients with non-AF heart failure(group C)were selected as the controls.The levels of serum NT-proBNP and Lp-PLA2 sin all cases were measured,and the echocardiography and ECG examinations were conducted.Results The serum LpPLA2 and NT-proBNP levels were the highest in the group A,which were the lowest in the group B and the difference among 3 groups had statistical significance(P<0.05).The LVEF level in the patients of the group A was the lowest,which in the group B was the highest,and the difference among 3 groups had statistical significance(P<0.05).Lp-PLA2 in the patients with AF complicating heart failure had a positive correlation with NT-proBNP(P<0.05)and a negative correlation with LVEF(P<0.05).The higher the Lp-PLA2 level,and the worse the heart function.Conclusion The serum Lp-PLA2 level in the patients with AF complicating heart failure may better reflect the heart function.更多还原