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超临界二氧化碳辅助制备β-环糊精-药物包合物的研究进展
Preparation of β-cyclodextrin-drug Inclusion Complex Aided by Supercritical Carbon Dioxide
【摘要】 β-环糊精是一种具有良好生物相容性的可降解生物材料,被广泛应用于医药、医疗和环境等领域。本文首先阐述了β-环糊精的基本性质及其在药剂学相关领域的应用,简要论述了超临界流体作为绿色溶剂的一些特点及其在药物制剂中的应用情况,介绍了超临界二氧化碳制备β-环糊精包合物的一些研究方法和结果,最后对β-环糊精的应用和超临界流体的研究发展方向进行了展望。
【Abstract】 Due to its good biocompatibility and biodegradability,β-cyclodextrin is widely used in the fields of the drug,medicine and environment and so on. In this paper,the basic properties of β-cyclodextrin and its application in pharmaceutical fields were described,and the characteristics of supercritical fluid as a green solvent and its application in pharmaceutical preparations were briefly discussed. Some research methods and results on β-cyclodextrin inclusion complex prepared by supercritical carbon dioxide were introduced. Finally,the development direction on the application of β-cyclodextrin and the research of supercritical fluid were prospected.
【Key words】 β-cyclodextrin; supercritical carbon dioxide; β-cyclodextrin inclusion complex; drug microparticles;
- 【文献出处】 材料导报 ,Materials Reports , 编辑部邮箱 ,2019年S2期
- 【分类号】TQ460.1
- 【被引频次】1
- 【下载频次】422