【摘要】 目的:探讨姜黄素对骨质疏松大鼠种植体骨结合的影响,阐明其的作用机制。方法:45只大鼠随机分为对照组(植入螺纹钉)、模型组(骨质疏松模型+植入螺纹钉)和姜黄素组(骨质疏松模型+植入螺纹钉+姜黄素治疗),每组15只。显微CT检查各组大鼠种植体周围骨组织的相对骨体积分数(BV/TV)、平均骨小梁粗度(Tb.Th)、骨小梁间隙(Tb.Sp)、平均骨小梁数量(Tb.N)和骨结合指数(OI),亚甲基蓝-碱性品红染色检查骨组织形态表现,计算骨结合率和松质骨区骨量,扭矩测试仪测定种植体脱位扭矩。结果:与对照组比较,模型组和姜黄素组大鼠种植体周围骨界面BV/TV、Tb.Th、Tb.N、OI、骨结合率、松质骨区骨量和脱位扭矩均明显降低(P<0.01),Tb.Sp明显升高(P<0.01);与模型组比较,姜黄素组大鼠种植体周围骨界面BV/TV、Tb.Th、Tb.N、OI、骨结合率、松质骨区骨量和脱位扭矩明显升高(P<0.01),Tb.Sp明显降低(P<0.01)。对照组大鼠种植体和骨结合紧密,种植体骨结合界面骨板较厚,骨小梁较密集;模型组大鼠种植体骨结合界面骨板比较薄,骨小梁稀疏;姜黄素组大鼠种植体骨结合界面骨板较厚,骨小梁较密集。结论:姜黄素可促进骨质疏松大鼠种植体愈合,改善种植体骨结合强度,增加种植体稳定性。更多还原

【Abstract】 Objective:To investigate the effect of curcumin on the implant osseointegration in the rats with osteoporosis,and to clarify its mechanism.Methods:A total of 45 rats were randomly divided into control group(screw implant),model group(osteoporosis model+ screw implant)and curcumin group(osteoporosis model+screw implant+curcumin treatment),with 15 rats in each group.The micro-CT was used to examine the relative bone volume fraction(BV/TV),average bone trabecular thickness(Tb.Th),trabecular space(Tb.Sp),average bone trabecular number(Tb.N),osseointegration index(OI)of the bone tissue around the implants of the rats in various groups;methylene blue-basic fuchsin staining was used to examine the morphology of bone tissue;the bone contact rate and the bone mass in cancellous bone area were calculated.The torque tester was used to measure the implant dislocation torque.Results:Compared with control group,the BV/TV,Tb.Th,Tb.N,OI,the bone contact rates,the bone mass in cancellous bone area,and the dislocation torque of bone interface around the implants of the rats in model group and curcumin group were significantly decreased(P<0.01),while Tb.Sp in model group and curcumin group were significantly increased(P <0.01).Compared with model group,the BV/TV,Tb.Th,Tb.N,OI,the bone contact rate,the bone mass in cancellous bone area,and the dislocation torque of bone interface around the implants of the rats in curcumin group were increased(P<0.01),while Tb.Sp was significantly decreased(P<0.01).In control group,the bonding of implant and bone was close,and the bone plate and trabeculae at the bonding interface of implant and bone were thicker and denser.In model group,the bone plate at the bonding interface of implant and bone was thin and the trabecular bone was sparse.In curcumin group,the bone plate and trabeculae at bonding interface of the implant and bone of the rats were thicker and denser.Conclusion:Curcumin can promote the implant healing,improve the implant and bone bonding strength and increase the implant stability in the osteoporosis rats.更多还原