【摘要】 目的探讨趋化因子受体7(CXCR7)在胃癌患者胃癌组织中的表达情况及其与患者临床特征的关系。方法选取104例胃癌患者的胃癌组织标本、104例癌旁黏膜组织标本和50例行胃次全切除术的胃部良性病变患者的正常胃黏膜组织标本,采用免疫组织化学法和免疫荧光双染法检测胃癌组织、癌旁黏膜组织和正常胃黏膜组织中CXCR7的表达情况,并分析CXCR7在胃癌组织中的表达情况与患者临床特征的关系。结果胃癌组织中CXCR7的阳性表达率明显高于正常胃黏膜组织和癌旁黏膜组织(P﹤0.01)。肿瘤直径≥5 cm、TNM分期为Ⅲ～Ⅳ期、有淋巴结转移、低分化、侵及浆膜的胃癌患者胃癌组织中CXCR7的阳性表达率均高于肿瘤直径﹤5 cm、TNM分期为Ⅰ～Ⅱ期、无淋巴结转移、中高分化、未侵及浆膜的胃癌患者(P﹤0.05)。Spearman轶相关分析结果显示,肿瘤直径、TNM分期、淋巴结转移情况、浸润深度均与CXCR7的表达呈明显正相关(r=0.538、0.627、0.569、0.597,P﹤0.01);分化程度与CXCR7的表达呈明显负相关(r=-0.513,P﹤0.01)。结论 CXCR7在胃癌组织中的阳性表达率较高,其对胃癌的诊断具有较高的应用价值,有助于临床医师对胃癌的进展情况进行判断。更多还原

【Abstract】 Objective To investigate the expression of C-X-C chemokine receptor 7(CXCR7) in the tissues of patients with gastric carcinoma and the relationship with clinical characteristics. Method The gastric carcinoma tissue specimens and adjacent mucosal tissues specimens from 104 patients with gastric carcinoma and normal gastric mucosal tissue specimens from 50 patients with benign gastric lesions underwent subtotal gastrectomy were selected. The expressions of CXCR7 in the carcinoma tissues, adjacent mucosal tissues and normal gastric mucosal tissues were detected by immunohistochemistry and immunofluorescence double staining. The relationship between the expression of CXCR7 and the clinical characteristics of gastric carcinoma patients was analyzed. Result The positive expression rate of CXCR7 in the gastric carcinoma tissues was significantly higher than that in the normal gastric mucosal tissues and adjacent mucosal tissues(P<0.01). The positive expression rates of CXCR7 in the patients with tumor diameter ≥5 cm, TNM stage Ⅲ toⅣ, positive lymph node metastasis, poorly differentiated, positive serosa invasion were significantly higher than those with tumor diameter <5 cm, TNM stage Ⅰ toⅡ, negative lymph node metastasis, moderately-well differentiated and negative serosa invasion(P<0.05). The Spearman level correlation analysis showed that the tumor diameter, TNM stage, the lymph node metastasis, invasion depth were positively correlated with CXCR7 expression(r=0.538, 0.627, 0.569, 0.597,P<0.01). The degree of cell differentiation was negatively correlated with CXCR7 expression(r=-0.513, P<0.01).Conclusion The positive expression rate of CXCR7 in gastric cancer tissues is high. It has high application value in the diagnosis of gastric carcinoma. CXCR7 detection is helpful for the clinician to judge the progress of gastric carcinoma.更多还原