【摘要】 目的:评估DNA甲基转移酶3B-149C>T(DNMT3B-149C>T)多态性与致癌风险之间的相关性。方法:依据Newcastle-Ottawa Scale(NOS)文献质量评价量表,对1990～2017年国内外公开发表的相关文献进行评价并提取资料;对DNMT3B-149C>T各基因型模型进行比较,包括CC与TT、CT与TT、CC+CT与TT,综合分析其在病例组和对照组中的分布情况;通过Q检验和I~2值分析各研究间的异质性,应用Begg秩相关法和Egger回归法验证发表偏倚,使用Review Manager 5.0软件和STATA version 12.0进行统计分析,计算比值比(OR)及95%置信区间(95%CI),评估DNMT3B-149C>T多态性与致癌风险的相关性。结果:分析文献中的7 612名癌症病例和9 679名健康对照。按不同癌症类型进行亚组分析,DNMT3B-149C>T多态性与肺癌的患病存在相关性[OR=1.51,95%CI(1.08,2.12),P=0.02]。结论:DNMT3B-149C>T多态性可能是肺癌的易感性因素。更多还原

【Abstract】 OBJECTIVE: To assess the associations between polymorphism of DNA methyltransferase 3B-149C>T(DNMT3 B-149C>T) and cancer risk. METHODS: We evaluated and extracted the relevant literatures published from 1990 to 2017 based on Newcastle-Ottawa Scale(NOS). All genotype models of DNMT3B-149C>T were compared, including CC and TT,CT and TT,CC + CT and TT,and their distillations in case and control groups were comprehensively analyzed. Q-test and 12 value were used to analyze the heterogeneity among the studies. Begg and Egger regressions were used to verify the evaluation of publication bias, and Review Manager 5.0 and ST AT A version 12.0 software were used for Meta-analysis. The correlation between polymorphism of DNMT3B-149C>T and cancer risk was calculated by using the odds ratio(OR) and 95%confidence interval(95%CI). RESULTS: 7 612 cancer cases and 9 679 healthy controls in the literature were analyzed. According to subgroup analysis of different cancer types, the DNMT3B-149C>T polymorphism was associated with lung cancer [OR=1.51,95% CI(1.08, 2.12), P=0.02]. CONCLUSION: DNMT3B-149C>T polymorphism may be a susceptibility factor for lung cancer.更多还原