【摘要】 采用电喷雾离子化-高分辨质谱(ESI-HRMS)法对梓醇丙酰化产物进行定性确认,利用峰面积归一化法对各产物进行半定量分析,建立了梓醇丙酰化过程分析方法.结果表明:ESI-HRMS法可以快速定性丙酰化产物的种类,而峰面积归一法可以计算得到各梓醇丙酰化产物的相对含量,由此可以根据需要,通过控制反应条件,合成有特定结构的主产物或混合产物.ESI-HRMS法在梓醇丙酰化过程分析中的应用,为梓醇丙酰化产物合成过程分析提供了新途径.更多还原

【Abstract】 Using electrospray ionization-high resolution mass spectrometry( ESI-HRMS) method to confirm the catalpol propionylated products,and using peak area normalizing method to complete the semi quantitative,the analysis method on the synthesize process of catalpol propionylated products was established. The results showed that the ESI-HRMS method could quickly determine the type of propionylated products; the peak area normalization method could calculate the relative content of each catalpol propionylated products,which could be controlled to synthesize the main or mixed products with the specific structure by controlling the reaction conditions according to the need. The application of ESI-HRMS method in the reaction process of catalpol propanolation could provide a new approach for the analysis of the synthesis process of catalpol propanylated products.更多还原