【摘要】 目的:探讨用于治疗骨折延迟愈合和骨折不愈合的中药汤剂的用药规律。方法:应用计算机检索中国知网、万方数据、维普网及中国生物医学文献数据库建库至2018年6月1日收录的所有口服中药汤剂治疗骨折延迟愈合和骨折不愈合的文献。通过阅读题目、摘要及全文筛选文献,提取文献中涉及的方剂及药物,分析用药规律。结果:最初共检索到2203篇文献,通过筛选后纳入110篇文献,涉及方剂115首、药物57种,57种药物共出现1151次。57种药物中,出现频次≥20次的药物有22种,按照出现频次从高至低排在前10位的依次为当归(79次)、骨碎补(65次)、熟地黄(61次)、续断(56次)、甘草(51次)、自然铜(46次)、黄芪(45次)、丹参(41次)、牛膝(40次)、川芎(38次)。57种药物涉及的药性包括温、平、寒、热,以温(639次)、平(329次)、寒(177次)为主;酸、苦、甘、辛、咸、淡、涩7种药味均有涉及,以甘(788次)、苦(512次)、辛(441次)味药为主;归各脏腑经络的药物均有,以归肝经(860次)、肾经(509次)、脾经(454次)、心经(343次)、肺经(207次)、胃经(141次)药物为主; 57种药物中具有活血化瘀(452次)、和营止痛(285次)、接骨续筋(247次)、补益肝肾(242次)、补气养血(146次)、补脾养胃(125次)作用的药物出现的频次较多。结论:用于骨折延迟愈合和骨折不愈合的中药汤剂中的高频中药包括当归、骨碎补、熟地黄、续断、甘草、自然铜、黄芪、丹参、牛膝、川芎,药性以温、平、寒为主,药味以甘、苦、辛为主,归经以归肝经、肾经、脾经、心经、肺经、胃经为主,功效以活血化瘀、和营止痛、接骨续筋、补益肝肾、补气养血、补脾养胃为主。更多还原

【Abstract】 Objective: To explore the medication rule of Traditional Chinese Medicine( TCM) decoctions for treatment of delayed unionand nonunion of fractures. Methods: All articles about oral application of TCM decoctions for treatment of delayed union and nonunion offractures included from database establishing to June 1,2018 were retrieved from China national knowledge internet,Wan Fang Data,VIPDatabase and Chinese biomedical literature database through computer. The articles were screened through reading titles,abstracts and fulltexts,and the prescriptions and drugs involved in the articles were searched out,and their medication rules were analyzed. Results: Twothousand two hundred and three articles were searched out. After screening,110 articles were included in the final analysis,including 115 prescriptions and 57 drugs( total frequency was 1151). In 57 drugs,the occurrence frequency of 22 drugs were ≥ 20,and the top 10 drugswith high occurrence frequency included Chinese angelica( 79 times),drynaria fortunei( 65 times),radix rehmanniae praeparata( 61times),dipsacus asper( 56 times),radix glycyrrhiza( 51 times),pyritum( 46 times),astragalus membranaceus( 45 times),salvia miltiorrhi-za( 41 times),achyranthes bidentata( 40 times) and ligusticum chuanxiong( 38 times) in turn. For the 57 drugs,the drug properties includedwarm,normal,cold and hot and presented mainly with warm( 639 times),normal( 329 times) and cold( 177 times); the drug flavours includ-ed sour,bitter,sweet,pungent,salty,bland and astringency and presented mainly with sweet( 788 times),bitter( 512 times) and pungent( 441 times); the meridian distributions included all entrails meridians and presented mainly with liver meridian( 860 times),kidney merid-ian( 509 times),spleen meridian( 454 times),heart meridiam( 343 times),lung meridian( 207 times) and stomach meridian( 141 times);the clinical effects presented mainly with activating blood and resolving stasis( 452 times),harmonizing nutrient and relieving pain( 285times),reuniting ruptured sinews and bones( 247 times),tonifying liver and kidney( 242 times),tonifying qi and nourishing blood( 146times) and tonifying spleen and nourishing stomach( 125 times). Conclusion: The Chinese drugs with high occurrence frequency in TCMdecoctions which are used for treatment of delayed union and nonunion of fractures include Chinese angelica,drynaria fortunei,radix reh-manniae praeparata,dipsacus asper,radix glycyrrhiza,pyritum,astragalus membranaceus,salvia miltiorrhiza,achyranthes bidentata and ligu-sticum chuanxiong. Their drug properties present mainly with warm,normal and cold; and their drug flavours present mainly with sweet,bit-ter and pungent. Their meridian distributions present mainly with liver meridian,kidney meridian,spleen meridian,heart meridiam,lung me-ridian and stomach meridian; and their clinical effects present mainly with activating blood and resolving stasis,harmonizing nutrient and re-lieving pain,reuniting ruptured sinews and bones,tonifying liver and kidney,tonifying qi and nourishing blood and tonifying spleen andnourishing stomach.更多还原