【摘要】 目的探讨济宁地区高龄孕妇进行羊水染色体核型分析的必要性。方法选取在我院遗传门诊咨询的高龄孕妇(预产年龄≥35岁)1367例,同时选取血清学筛查高风险孕妇1810例作为对照,抽取羊水进行胎儿染色体核型分析。结果1367例高龄孕妇中羊水染色体异常79例,染色体异常发生率5.78%;1810例高风险孕妇羊水染色体异常65例,染色体异常发生率3.59%,经统计学χ~2检验分析,χ~2=8.62(P<0.01)。结论高龄孕妇胎儿染色体异常发生率显著高于血清学筛查高风险孕妇,对高龄孕妇进行遗传咨询和必要的羊水产前诊断意义重大,可有效防止染色体异常胎儿出生,降低济宁地区的出生缺陷。更多还原

【Abstract】 Objective:To explore the necessity of karyotype analysis of amniotic fluid in elderly women(≥35) in Jining area. Methods:To analyze the fetus’ s chromosome,choosing 1367 elderly pregnant women(age at birth≥35) who consulted in genetic clinic in our hospital and 1810 non advanced pregnant women of serological screening high risk from the process of extracting amniotic fluid. Results:Among 1367 elderly pregnant women,the number of non polymorphic chromosomal abnormality is 79 and the incidence of chromosomal abnormality is 5.78%;Among 1810 high risk pregnant woman,the number of non polymorphic chromosomal abnormality is 65 and the incidence of chromosomal abnormality is 3.59%;By statistical analysis,χ~2=8.62(P<0.01). Conclusion:The incidence of fetus’ s chromosomal abnormality of the elderly pregnant women is remarkably higher than serological screening high risk pregnant woman. And it is significant to do genetic counseling and necessary amniotic fluid pregnant diagnosis for elderly pregnant women which can efficiently prevent the birth defects in the Jining region.更多还原