目的:研究冬连三七组分(Composition of Ophiopogon polysaccharide,Notoginseng total saponins and Rhizoma Coptidis alkaloids,CONR)调控AGEs/p38MAPK信号转导通路,改善糖尿病动脉粥样硬化(diabetic atherosclerosis,DA)兔血管内皮损伤的机制。方法:雄性新西兰大白兔分为空白组、模型组、CONR高剂量组、CONR低剂量组、SB203580组、辛伐他汀组;静脉推注四氧嘧啶并且配合腹主动脉内膜球囊损伤术诱导DA模型。CONR高、低剂量组每日分别给予CONR 450 mg/kg、CONR 150 mg/kg灌胃10周;辛伐他汀组给予3 mg/kg辛代他汀灌胃10周;SB203580组给予p38MAPK抑制剂2 mg/kg腹腔注射,12 h重复给药10周;空白组每日给予生理盐水20 ml灌胃。结果:各实验组对AGEs高表达均有降低作用,与模型组比较差异具有统计学意义。各实验组对p-p38MAPK蛋白高表达均有抑制作用,与模型组比较,差异具有统计学差异(P<0.01)。CONR高、辛伐他汀组...
【英文摘要】
Objective: To study the effects of CONR( Composition of Ophiopogon polysaccharide,Notoginseng total saponins and Rhizoma Coptidis alkaloids) on vascular endothelial injury in rabbits with diabetic atherosclerosis( DA) by regulating AGEs/p38 MAPK signaling pathway. Methods: The rabbits were randomly divided into the blank group( 20 ml normal saline),the model group,CONR high-dose group( 450 mg/kg),CONR low-dose group( 150 mg/kg),SB203580 group( 2 mg/kg),and Simvastatin group( 3 mg/kg). DA models were establi...
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