【摘要】 目的:考察布洛芬（IPF）肠溶滴丸单次给药在Beagle犬体内的药物动力学特性。方法:实验动物随机分为2组,每组各3只,分别给予同剂量的市售IPF片或IPF肠溶滴丸,在预定时间点取血样检测血浆中药浓,用DAS 2. 0软件进行模型拟合及药动学参数计算,并进行生物等效性评价。结果:市售IPF片、IPF肠溶滴丸在犬体内药动学均符合单室模型,与IPF片相比,IPF肠溶滴丸的C_max,AUC_0-∞均有显著增加,T_max滞后,且差异均有统计学意义（P <0. 05）,其相对生物利用度为（205. 89±4. 04）%。结论:与市售IPF片相比,IPF肠溶滴丸在犬体内达峰时间滞后,但达峰浓度及生物利用度显著增加,显示肠溶性及高效性。更多还原

【Abstract】 Objective: To study the pharmacokinetics of ibuprofen（ IPF） enteric-coated dropping pills in Beagle dogs after single oral administration. Methods: Beagle dogs were randomly divided into two groups with 3 ones in each,and respectively given the marketed IPF tablets and IPF enteric-coated dropping pills with the same dosage. At the predetermined time points,the plasma IPF concentration was detected. DAS 2. 0 software was applied in the model fit and parameter calculation,and the bioequivalence was also evaluated. Results: Both the marketed IPF tablets and the enteric-coated dropping pills were fitted one-compartment models. Compared with those of IPF tablets,the C_max and AUC_0-∞of IPF enteric-coated dropping pills showed notable increase,and T_max delayed significantly（ P < 0. 05）. The relative bioavailability of the dropping pills was（205. 89 ± 4. 04） %. Conclusion: Compared with the marketed IPF tablets,IPF enteric-coated dropping pills are with delayed T_max and increased C_max and AUC,suggesting notable enteric release and high efficacy.更多还原