【摘要】 目的:探讨寻常型银屑病患者行308nm高能准分子光和卡泊三醇倍他米松软膏联合治疗的效果,评定临床价值。方法:选入我院于2016年1月-2017年1月所收治的寻常型银屑病患者共90例,采用随机数字表法的形式将其平均分为联合治疗组(n=30)、药物组(n=30)以及准分子光组(n=30)。对比三组患者予以不同方法治疗后的疗效、不同治疗周期的DLQI评分、治愈皮损照射次数和剂量以及不良反应发生率和随访情况。结果:三组患者治疗后2、4、6、8周PASI和DLQI评分均逐渐下降、PASI评分及DLQI评分在疗后2周3组评分差异不具有统计学意义(P>0.05),治疗后4、6、8周药物组、准分子光组以及联合治疗组之间差异均有统计学意义(P<0.05),3组患者治疗8周后的有效率差异具有统计学意义(χ~2=7.52,P=0.023),其中联合治疗组分别与药物组及准分子光组有效率差异均有统计学意义(P<0.05),可以认为联合治疗组有效率高于药物组准分子光组。3组治疗结束后复查血尿常规、肝肾功能均无异常。结论:采用308nm高能准分子光和卡泊三醇倍他米松软膏联合治疗慢性斑块状银屑病的效果显著,临床安全性高,值得临床进一步应用。更多还原

【Abstract】 Objective: To evaluate the clinical effect of 308 nm high-energy excimer light and calcitriol betamethasone ointment on psoriasis vulgaris. Methods: 90 patients were randomly divided into the combined treatment group(n=30), meidicne group(n=30) and excimer light group(n=30). The curative effect, the DLQI score of different cycles, the frequency and dose of cured skin lesions and the incidence of adverse reactions and follow-up were compared among three groups. Results: After The 2, 4, 6 and 8 weeks, PASI and DLQI scores were decreased gradually. There was no significant difference of PASI score and DLQI score among groups after 2 weeks(P>0.05). There was significant differences among groups after 4, 6, 8 weeks(P<0.05); and there was a significant difference of efficiency among 3 groups after 8 weeks of treatment(χ~2=7.52, P=0.023). The efficiency in the combined treatment group was more efficient than the excimer light group. Hematuria routine review indicated no abnormal liver and kidney function in 3 groups after treatment. Conclusion: The combination of 308 nm high-energy excimer light and calcitriol betamethasone ointment on chronic plaque psoriasis showed a significant effect and high clinical safety, which was worthy of further clinical application.更多还原