【摘要】 目的观察知柏地黄丸加减辅助治疗女童特发性性早熟的临床疗效。方法 88例女童特发性性早熟患儿随机分为对照组和治疗组,各44例,对照组给予曲普瑞林治疗,治疗组在对照组治疗方法的基础上给予知柏地黄丸加减治疗,治疗6月后统计2组的疗效及安全性。结果治疗组总有效率为90.91%,明显高于对照组的70.46%,经统计学分析,差异有统计学意义(P<0.05)。2组治疗前子宫容积、卵巢容积、卵泡直径、骨龄与生活年龄比值(△BA/△CA)比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组上述指标均有所改善,与同组治疗前比较,差异有统计学意义(P<0.05);治疗后2组间子宫容积、卵巢容积、卵泡直径比较,差异均无统计学意义(P>0.05),仅△BA/△CA值明显低于对照组(P<0.05)。2组治疗前黄体生成素(LH),卵泡刺激素(FSH)水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组LH,FSH水平均明显改善,与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组改善更明显(P<0.05)。2组不良反应发生情况比较,差异无统计学意义(P>0.05)。结论知柏地黄丸辅助治疗女童特发性性早熟临床疗效显著,能延缓患儿骨龄的发育,改善性激素水平,且安全性高。更多还原

【Abstract】 Objective To observe the clinical effect of modified Zhibai Dihuang Pills as an adjunctive therapy in treating of girls with idiopathic precocious puberty. Methods 88 girls with idiopathic precocious puberty were divided into therapy group and control group with 44 cases in each. The control group was treated with Triptorelin and the therapy group was treated with modified Zhibai Dihuang Pill based on the treatment of control group. The clinical effect and safety of two groups were observed after treated 6 months. Results The total effective rate in therapy group( 90.91%) was significantly higher than that in the control group( 70.46%),difference had significance( P<0.05).The uterine volume,ovarian volume,follicle diameter and the △BA/△CA in two groups showed no differences before treatment( P>0.05).After treatment,each index was improved,which showed differences comparing that in the same group before treatment( P<0.05); there were no significant differences in uterine volume,ovarian volume and follicle diameter of two groups after treatment( P>0.05),and the △BA/△CA value of therapy group was significantly lower than that in the control group( P<0.05). There were no significant differences in LH and FSH of two groups before treatment( P>0.05); but after treatment,they both improved significantly,which had showed significant differences comparing that in the same group before treatment( P < 0. 05),and they improved more in therapy group( P < 0. 05). The adverse reactions were no significant differences between the two groups( P>0.05).Conclusion Zhibai Dihuang Pills,as an adjunctive therapy,can treat girls with idiopathic precocious puberty effectively,which can delay the development of bone age in children and improve sex hormone with high security.更多还原