【摘要】 目的:探讨双C疗法治疗高龄孕妇妊娠期糖尿病(gestational diabetes mellitus,GDM)并妊娠期高血压疾病的可行性。方法:选取2016年1月-2017年12月本院收治的GDM并妊娠期高血压疾病的高龄孕妇140例。根据随机数字表法将其分为观察组和对照组,各70例。对照组给予常规治疗,观察组给予双C疗法。比较两组孕妇治疗前后的血糖(FBG、2 h PG、Hb A1c)、血压(SBP、DBP)、肾功能(Cys C、RBP),新生儿FBG、1 h血糖(1 h PG),不良情况和血糖达标时间。结果:治疗后,观察组孕妇FBG、2 h PG、Hb A1c、SBP、DBP、Cys C、RBP均低于对照组,比较差异均有统计学意义(P<0.05);观察组新生儿FBG、1 h PG水平均低于对照组,比较差异均有统计学意义(P<0.05);观察组低血糖(孕妇及新生儿)和孕妇黎明现象的发生率、血糖达标时间均低于对照组,比较差异均有统计学意义(P<0.05)。结论:相较于常规疗法,双C疗法治疗高龄孕妇GDM并妊娠期高血压疾病的效果更为显著,可有效改善孕妇和新生儿的血糖、血压水平和肾功能,在降低低血糖和黎明现象的发生率等方面均表现出显著优势,因而值得在临床上进行推广应用。更多还原

【Abstract】 Objective:To investigate the feasibility of double C therapy for gestational diabetes mellitus(GDM) and hypertensive disorder complicating pregnancy in elderly pregnant women.Method:A total of 140 elderly pregnant women with GDM and hypertensive disorder complicating pregnancy admitted to our hospital from January 2016 to December 2017 were selected.According to the random number method,they were divided into observation group and control group,70 cases in each group.The control group was given conventional treatment,and observation group was given double C therapy.The blood glucose(FBG,2hPG,HbA1c),blood pressure(SBP,DBP),renal function(Cys C,RBP) before and after treatment in pregnant women,FBG and 1 h plasma glucose(1hPG) in neonatus,bad condition and blood glucose standard time between two groups were compared.Result:After treatment,the levels of FBG,2hPG,HbA1c,SBP,DBP,Cys C and RBP in observationgroup were lower than those of control group,the differences were statistically significant(P<0.05).The FBG and 1 h PG of neonates in observation group were lower than those of control group,the differences were statistically significant(P<0.05).The incidence of hypoglycemia(pregnant women and neonatus) and pregnant women’s dawn phenomenon and blood glucose standard time in observation group were lower than those of control group,the differences was statistically significant(P<0.05).Conclusion:Compared with conventional therapy,double C therapy is more effective in the treatment of GDM and hypertensive disorder complicating pregnancy in elderly pregnant women,can effectively improve maternal and neonatal blood glucose levels,blood pressure levels and renal function,has obvious advantages in reducing the incidence of hypoglycemia and dawn phenomenon,and is worthy of clinical application.更多还原