【摘要】 [目的]研究复方清降保龄液联合多烯磷脂酰胆碱胶囊治疗非酒精性脂肪肝病(NAFLD)的临床疗效及对患者血脂、肝功能和肝纤维化指标的影响,旨在为更好地治疗NAFLD痰瘀互结证患者提供有效的理论依据。[方法]选取2015年11月~2017年11月期间本院收治的100例NAFLD痰瘀互结证患者作为研究对象,按照随机数字表法分成对照组与中药组,每组50例,对照组患者采用多烯磷脂酰胆碱胶囊治疗,中药组患者采用复方清降保龄液联合多烯磷脂酰胆碱胶囊治疗。观察并比较不同治疗方式对2组患者的临床疗效以及对血脂、肝功能、肝纤维化指标及不良反应情况。[结果](1)中药组治疗后总有效率明显高于对照组(92.00%vs.70.00%)(P<0.05);(2)2组治疗前甘油三脂(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDLC)水平比较,差异无统计学意义;2组治疗后TG、TC及LDL-C水平均降低,HDL-C水平升高,且中药组改变幅度明显大于对照组(P<0.05);(3)2组治疗前丙氨酸转氨酶(ALT)、天氨酸转氨酶(AST)、γ-谷氨酰转肽酶(γ-GT)水平比较,差异无统计学意义;2组治疗后ALT、AST、γ-GT水平均降低,且中药组改变幅度明显大于对照组(P<0.05);(4)2组治疗前Ⅲ型前胶原(PC-Ⅲ)、层粘连蛋白(LN)、透明质酸(HA)水平比较,差异无统计学意义;2组治疗后PC-Ⅲ、LN、HA水平均降低,且中药组改变幅度明显大于对照组(P<0.05);(5)2组均未发现明显不良反应。[结论]复方清降保龄液联合多烯磷脂酰胆碱胶囊治疗NAFLD痰瘀互结证患者可显著提高临床疗效,可改善血脂、肝功能及肝纤维化,无明显不良反应,安全性好。更多还原

【Abstract】 [Objective]To investigate the effect of compound Qingjiang Baoling decoction combined with polyene phosphatidylcholine capsules on serum lipid,liver function and liver fibrosis of patients with nonalcoholic fatty liver disease(NAFLD),aiming to provide an effective theoretical basis for better treatment of NAFLD patients with intermingled phlegm and blood stasis syndrome.[Methods]A total of 100 NAFLD patients with intermingled phlegm and blood stasis syndrome treated in our hospital from November 2015 to November 2017 were selected and equally divided into two groups according to the random number table.The control group received the polyene phosphatidylcholine capsules,based on this,the TCM group received the compound Qingjiang Baoling decoction.Then the clinical efficacy,blood lipid,liver function,liverfibrosis indexes and adverse reactions of two groups were observed and compared.[Results](1) The total effective rate of TCM group after treatment was significantly higher than that of the control group(92.00%vs.70.00%,P<0.05);(2) The levels of triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C)and low-density lipoprotein cholesterol(LDL-C)had no difference before treatment.After treatment,the levels of TG,TC,and LDL-C were decreased and the level of HDL-C was increased,while both changes were more significant in the TCM group than those in the control group(P<0.05);(3) The levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),γ-glutamyl transpeptidase(γ-GT)had no difference before treatment,which were decreased after treatment,and were lower in the TCM group than those in the control group(P<0.05);(4) The levels of precollagen Ⅲ(PCⅢ),laminin(LN)and hyaluronic acid(HA)had no difference before treatment,which were decreased after treatment,and were lower in the TCM group than those in the control group(P<0.05);(5) No obvious adverse reactions were found in both groups.[Conclusion]The compound Qingjiang Baoling decoction combined with polyene phosphatidylcholine capsules can safely and effectively ameliorate the blood lipids,liver function and liver fibrosis for NAFLD patients with intermingled phlegm and blood stasis syndrome,which has no obvious adverse reactions.更多还原