【摘要】 目的分析雷珠单抗联合光动力疗法(PDT)治疗湿性年龄相关性黄斑变性的黄斑形态学变化。方法收集湿性年龄相关性黄斑变性患者57例(1眼/例)并分为观察组30例(雷珠单抗联合光动力疗法)和对照组27例(雷珠单抗单药治疗)。比较两组治疗后黄斑形态学的变化。结果治疗后黄斑中心凹厚度(CMT)及病变面积均呈下降趋势(P <0.05),观察组下降幅度高于对照组。治疗后1个月下降幅度最大,观察组和对照组CMT下降幅度分别为(87.5±12.8)和(60.1±16.6)μm;观察组和对照组黄斑病变面积减少幅度分别为(2.5±0.6)和(1.8±0.7)mm~2。治疗后12个月观察组和对照组黄斑病变面积减少有效率分别为93.3%和77.8%。结论与单药治疗相比,雷珠单抗联合光动力疗法更能提高黄斑形态学改善的效果。更多还原

【Abstract】 Objective To retrospectively analyze morphological change of macula in wet age-related macular degeneration(wAMD) after treatment of Ranibizumab combined with photodynamic therapy(PDT).Methods Fifty-seven patients(57 eyes) with wAMD were assigned to observed group(30 eyes) with the regimen of Ranibizumab combined with PDT and control group(27 eyes) with Ranibizumab monotherapy. The change of macular morphology including the central macular thickness(CMT) and area of lesion(AOL) in macular between the two groups werecompared. Results After treatment, both CMT and AOL decreased over time compared with the baseline(P < 0.05). The declines of CMT and AOL in the observed group were more marked than control group(P < 0.05). The declines of CMT and AOL were maximal at the first month after therapy. The decline of CMT was(87.5 ± 12.8) μm in the observed group and(60.1 ± 16.6) μm in control group. The decline of AOL was(2.5 ± 0.6) mm2 in observation group and(1.8 ± 0.7) mm2 in control group. At the twelfth month of follow-up, the effective rate of the improvement of AOL in the observed group(93.3%) was higher than the control group(77.8%)(P < 0.05). Conclusions Compared with the monotherapy, Ranibizumab combined with PDT towards wAMD is more effective in the improvement of macular morphology.更多还原